Cockcroft_Gault方程估算GFR对冠状动脉病变的评估  

Assessment of Glomerular Filtration Rate on Coronary Artery Lesions by Cockcroft_Gault Equation

作　　者：郑家胜[1] 俎德玲[1] 诸葛毅[2] 屠晓鸣[1] 金奇志[1] 

机构地区：[1]浙江省衢州市人民医院心血管内科,324000 [2]浙江省衢州职业技术学院医学院,324000

出　　处：《心脑血管病防治》2015年第2期104-106,共3页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：目的探讨Cockcroft_Gault方程估算肾小球滤过率与冠状动脉狭窄程度的研究。方法冠状动脉造影确定为冠心病者253例为冠心病组,以Gensini积分对冠状动脉病变程度进行评分并分级,168例冠状动脉粥样硬化狭窄程度<50%患者为对照组,通过Cockcroft_Gault方程估算两组患者的肾小球滤过率,分析冠状动脉病变与估算肾小球滤过率之间的关系。结果冠心病组与对照组的估算肾小球滤过率分别为:(61.13±11.10)[m L/(min×1.73m2)]和(77.92±11.80)[m L/(min×1.73m2)](P<0.05),差异有统计学意义。冠状动脉轻度、中度和重度病变组,估算肾小球滤过率分别为(66.73±14.56)[m L/(min×1.73m2)],(63.83±15.45)[m L/(min×1.73m2)]和(57.23±14.37)[m L/(min×1.73m2)],差异有统计学意义(P<0.05)。结论 Cockcroft_Gault方程估算的肾小球滤过率可作为评估冠状动脉病变的临床参考指标。Objective To discuss the research of the relationship between estimated glomerular filtration rate by Cockcroft-Gault equation and coronary artery stenosis degree in patients with coronary heart disease. Methods 253 patients with coronary heart disease were confirmed by coronary angiography as coronary heart disease group,and were graded the degree of coronary artery lesion by Gensini score,168 cases of patients with degree of coronary atherosclerosis stenosis 50% were selected as control group. Glomerular filtration rate of the patients from two groups were estimated by Cockcroft-Gault equation,and the relationship between coronary artery disease and glomerular filtration rate were analyzed. Results The glomerular filtration rate of coronary heart disease group and control group were（ 61. 13 ± 11. 10） [m L /（ min × 1. 73m^2） ]and（ 77. 92 ± 11. 80） [m L/（ min × 1. 73m^2） ]（ P〈0. 05） respectively,there were statistical significant differences. The glomerular filtration rates estimated by Cockcroft-Gault equation among patients from Mild coronary artery lesion group,moderate lesion group,severe lesion group were：（ 66. 73 ± 14. 56） [m L /（ min × 1. 73m^2） ],（ 63. 83 ± 15. 45） [m L/（ min × 1. 73m^2） ] and（ 57. 23 ±14. 37） [m L /（ min × 1. 73m^2） ]（ P〈0. 05） respectively,and there were statistical significant differences. Conclusions Glomerular filtration rate estimated by the Cockcroft-Gault equation may be used as clinical reference indicators for the evaluation of coronary artery pathological lesions in patients with coronary heart disease.

关 键 词：冠心病 估算肾小球滤过率 冠状血管造影术 

分 类 号：R541.4[医药卫生—心血管疾病]