原发性高血压与脂联素、脂蛋白相关磷脂酶A2的相关性  

Correlation between essential hypertension with serum adiponectin and lipoprotein associated phospholipase A2

作　　者：高凌俊[1] 谢祥妹 何凤屏[1] 黄志[2] 徐新[1] 黄志红[2] 

机构地区：[1]广东韶关粤北人民医院心内科,广东韶关512026 [2]广东韶关粤北人民医院老年病科,广东韶关512026

出　　处：《国际检验医学杂志》2015年第8期1026-1027,1031,共3页International Journal of Laboratory Medicine

基　　金：国家临床医药研究专项基金资助项目(L2012053)

摘　　要：目的探讨脂联素、脂蛋白相关磷脂酶A2与原发性高血压发生、发展的关系。方法收集60例原发性高血压患者,根据血压水平分组,高血压病1级、2级及3级各20例,同时选取健康对照20例,于肘静脉采取,采用ELISE法检测脂联素及脂蛋白相关磷脂酶A2的浓度,同时检测相关生化指标。结果 1、2、3级组脂联素的水平均低于健康对照组,且3级组脂联素水平明显低于1级组(P<0.01);相反,1、2、3级组脂蛋白相关磷脂酶A2的水平均高于健康对照组,且3级组脂蛋白相关磷脂酶A2水平明显高于1级组(P<0.05);血清脂联素和脂蛋白相关磷脂酶A2水平撑显著负相关(r=-0.772,P<0.05)。结论原发性高血压的发生、发展与脂联素、脂蛋白相关磷脂酶A2水平有密切关系。Objective To investigate the relations between adiponectin（APN） and lipoprotein associated phospholipase A2 （LP‐PLA2） with the development and progress of essential hypertension .Methods 60 patients with essential hypertension were collect‐ed and divided into 3 groups of the hypertension grade 1 ,2 ,3 groups according to the levels of blood pressure ,20 cases in each group .Contemporaneous 20 healthy controls were selected .The peripheral venous blood samples were collected from the cubital vein and the serum levels of APN and LP‐PLA2 were measured by ELISE .The related biochemical indicators were simultaneously detected .Results The serum APN levels in the hypertension grade 1 ,2 ,3 groups were significantly lower than that in the control group ,moreover which in the hypertension grade 3 group was significantly lower than that in the hypertension grade 1 group（P〈0 .05）;on the contrary ,serum levels of LP‐PLA2 in the hypertension grade 1 ,2 ,3 groups were significantly higher than that in the healthy control group ,moreover which in the hypertension grade 3 group was obviously higher than that in the hypertension grade 1 group（P〈0 .05）;serum APN was significantly negatively correlated with LP‐PLA2（r= -0 .772 ,P〈0 .05） .Conclusion Serum levels of APN and LP‐PLA2 are closely related with the development and progress of essential hypertension .

关 键 词：原发性高血压 脂联素 脂蛋白相关磷脂酶A2 

分 类 号：R544.1[医药卫生—心血管疾病]