滇白珠种子抗炎化学成分的研究  

Antiphlogistic Constituents from Gaultheria yunnanensis Seeds

作　　者：谢威[1,2] 樊丁珲[1] 尹丽[1] 潘桂生[1] 钟彤[1] 李俊[2] 

机构地区：[1]广西工业职业技术学院,广西南宁530003 [2]广西师范大学环境与资源学院,广西桂林541004

出　　处：《林产化学与工业》2015年第2期142-146,共5页Chemistry and Industry of Forest Products

基　　金：广西植物功能物质研究与利用重点实验室开放基金(FPRU2011-3);药用资源化学与药物分子工程教育部重点实验室基金(CMEMR2012-A21)

摘　　要：采用小鼠耳肿胀法对滇白珠种子75%乙醇提取物的石油醚、氯仿、乙酸乙酯、正丁醇萃取物和水溶部分的抗炎效果进行测试。结果表明乙酸乙酯萃取物能显著减轻二甲苯致炎小鼠的耳廓肿胀度。采用色谱技术分离抗炎效果较好的乙酸乙酯萃取物的化学成分,得到8个化合物。通过NMR、IR、MS等波谱法鉴定,8个化合物为:大黄素甲醚(1)、6-乙基-5-羟基-2,7-二甲氧基-1,4-萘醌(2)、杨梅素(3)、对苯二酚(4)、香草酸(5)、β-胡萝卜苷(6)、β-谷甾醇(7)和丁二酸(8)。以上所有化合物都为首次从滇白珠种子中分离得到。The extract parts of Gaultheria yunnanensis seeds, which were extracted with petroleum ether, chloroform, ethyl acetate, butanol, and water from 75% ethanol extract, were investigated through pharmacological experiments. The ethyl acetate extract was the antiphlogistic part. Through the use of chromatographic technology, eight compounds were isolated from the antiphlogistic part. Their structures were identified by spectroscopic analyses, such as NMR, IR and MS, etc.. They were physcion （ 1 ）, 6-ethyl-5-hydroxy-2,7-dimethoxy-1,4-naphthoquinone （2）, myricetin （3）, 1,4-dihydroxybenzene （4）, vanillic acid （5） , β-daucosterol （6） , β-sitosterol （7） and succinic acid （8）. All compounds were isolated from the plant seeds for the first time.

关 键 词：滇白珠种子 化学成分 结构鉴定 

分 类 号：TQ35[化学工程]