类风湿性关节炎与IL-1/IL-1Ra平衡关系的研究进展  

Reaearch advance between rheumatoid arthritis and IL-1 and IL-Ra balance

作　　者：汪洁[1,2] 岳野[1] 成文翔[1] 虎义平[1] 马应亚 王均[2] 张鹏[1] 

机构地区：[1]中国科学院深圳先进技术研究院转化医学研究与发展中心,深圳518055 [2]中国科学技术大学纳米学院,苏州215123

出　　处：《中国当代医药》2015年第12期30-35,共6页China Modern Medicine

基　　金：国家自然科学基金(81271952);广东省省级科技计划项目(2013B050800005);广东省深圳市科技计划项目(JCYJ20140610151856738);广东省深圳市科技研发资金项目(GJHZ20130417171414738)

摘　　要：类风湿性关节炎(RA)为常见的自身免疫疾病,其发生、发展与众多炎性因子相关,白细胞介素1(IL-1)是一种炎症反应的重要介质,在人体的自然反应和病理条件导致慢性炎症的发展中都有重要作用,然而在抗炎细胞因子的影响下,体外IL-1炎症作用可以被一个特别强大的抑制剂——IL-1受体拮抗剂(IL-1Ra)抑制或者消除。目前研究显示,IL-1通过与Ⅰ型IL-1受体结合,可激活系列信号转导通路进而诱发关节软骨和骨侵蚀,同时可诱导其他炎性因子表达,协同加剧关节破坏,而IL-1Ra可牢固结合Ⅰ型IL-1受体,抑制IL-1的生物学效应,因此,RA患者体内IL-1/IL-1Ra的动态平衡对于该病的转归至关重要。深入对RA发病中IL-1/IL-1Ra平衡的认识对该病的预防、治疗及转归具有重要作用。Rheumatoid arthritis is a common autoimmune disease.Many inflammatory cytokines are involved in the pathological process of RA,among which IL-1 is a kind of important inflammatory mediator playing a key role in the chronic inflammation progress in consequence of body’s natural responses or pathological conditions.Under the influ-ence of anti-inflammatory cytokine,however ,in vitro inflammatory effects of IL-1 can be inhibited or abolished by a particularly powerful inhibitor-IL-1Ra.The current study shows that IL-1 can combine with IL-1RⅠ and it can acti-vate signaling transduction pathway and contribute to the erosion of bone and articular cartilage.Furthermore,IL-1 may induce the expression of other inflammatory cytokine and aggravate joint destruction synergistically.On the contrary,IL-1Ra may compaginate IL-1RⅠ to inhibit the biological effect of IL-1.Therefore,the dynamic equilibrium of IL-1 and IL-1Ra has great importance to the prognosis of RA and it will be great significance.Understanding IL-1 and IL-1Ra balance in attack of RA has important role for prevention,treatment and outcome of this disease.

关 键 词：类风湿性关节炎 IL-1 IL-1RA 平衡 

分 类 号：R593.22[医药卫生—内科学]