多药耐药肺炎克雷伯菌致小儿肠炎52例调查  

Investigation on pediatric enteritis caused by multi-drug resistance Klebsiella pneumoniae in 52 cases

作　　者：何昀[1] 

机构地区：[1]广东省佛山市妇幼保健院,广东佛山528000

出　　处：《中国当代医药》2015年第12期138-140,共3页China Modern Medicine

摘　　要：目的：探讨多药耐药肺炎克雷伯菌引起小儿肠炎的临床特征、治疗问题以及药物试验，为今后临床实践提供参考和借鉴，以提高早期对其的鉴别和治疗。方法选择2012年1月~2014年1月本院收集的52例经粪便细菌培养证实的高产头孢菌素酶（AmpC）和产超广谱β-内酰胺酶（ESBLs）多药耐药肺炎克雷伯菌引起小儿肠炎的患者为研究对象，根据其临床资料进行回顾性分析和总结，探讨多药耐药肺炎克雷伯菌引起小儿肠炎的临床特征及治疗问题等。结果52例多药耐药肺炎克雷伯菌引起小儿肠炎的患者均与抗菌药物的不合理应用有关，通过给予合理的治疗后康复出院；多药耐药肺炎克雷伯菌对大多数的头孢菌素类抗菌药物产生耐药性，对亚胺培南的敏感性为100.0%。结论多药耐药肺炎克雷伯菌是引起小儿肠炎发生的重要病菌之一，年龄〈2岁的小儿容易发生慢性腹泻等，治疗方式应以调节肠道微生态平衡为主，给予维生素B族等对症治疗措施，促进患儿尽快恢复健康。Objective To explore the clinical characteristics,treatment,and drug trial of pediatric enteritis induced by multi-drug resistance Klebsiella pneumoniae in order to provide a reference for clinical practices in future and improve its early identification and treatment. Methods 52 patients with pediatric enteritis caused by multi-drug resistance Klebsiella pneumoniae which was confirmed by AmpC enzyme and extended spectrum beta lactamase （ESBLs） from stool bacterial culture were selected as research objects.According to their clinical data,the clinical characteristics and treatment of pediatric enteritis caused by multi-drug resistance Klebsiella pneumoniae were retrospectively analyzed and summarized. Results 52 patients with pediatric enteritis resulted from multi-drug resistance Klebsiella pneumoniae were associated with irrational use of antimicrobial drugs,and they were recovered and discharged from hospital after providing with reasonable treatment.Multi-resistance Klebsiella pneumoniae was in drug resistance agalnst the majority of antimicrobial drugs in cephalosporins,and its sensitivity to imipenem was 100.0%. Conclusion Multi-drug resistance Klebsiella pneumoniae is one of the important pathogenic bacteria leading to the occurrence of pediatric enteritis.Chil-dren with the age less than 2 years old are vulnerable to chronic diarrhea,etc.The therapeutic method focuses on adjust-ing intestinal microecological balance as well as symptomatic treatment including vitamin B group so as to promote getting well as soon as possible.

关 键 词：肺炎克雷伯菌 小儿肠炎 多药耐药 

分 类 号：R446.5[医药卫生—诊断学]