重型颅脑损伤后患者血清抗脑抗体水平变化及亚低温对脑保护作用的研究  

The protective effects of mild hypothermia on cerebral and levels of serum levels of anti-brain antibodies after severe traumatic brain injury

作　　者：赵诚[1] 杜贵胜[1] 张本超[1] 王明阳[1] 

机构地区：[1]青岛市黄岛区人民医院神经外二科,山东省青岛266400

出　　处：《中国基层医药》2015年第7期1044-1046,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：研究重型颅脑损伤后患者血清抗脑抗体水平的变化以及亚低温对脑的保护作用。方法选取重型颅脑损伤患者为Ⅰ组（n＝60例），另外选取健康体检者为Ⅱ组（n＝30例），按照随机数字表法将Ⅰ组分为A组（n＝30例）和B组（n＝30例），A组给予亚低温治疗，B组给予常温治疗，应用酶联免疫法吸附法测定各组血清中抗脑抗体水平，采用多普勒观察A组和B组治疗前后脑血流变化，并观察A组和B组格拉斯哥结局评分（GOS）。结果 Ⅰ组血清抗脑抗体水平为（0．59±0．02）U／mL，显著高于Ⅱ组的（0．38±0.01）U／mL，两组差异有统计学意义（t ＝9．192，P＝0．029）；治疗后 A 组血清抗脑抗体水平为（1．58±0．03）U／mL，显著低于B组的（1．82±0．04）U／mL，两组差异有统计学意义（t＝10．042，P＝0．019）；治疗后A组平均血流速度、脉搏指数以及GCS评分分别为（54．20±0．23）cm／s、（0．51±0．02）、（10．03±1．03）分，均显著优于B组的（40.03±0．04）cm／s、（0．72±0．02）、（8．12±0．02）分，两组差异有统计学意义（t＝9．892、10．041、9．189，P＝0．021、0．018、0．026）。结论重型颅脑损伤后患者血清中抗脑抗体水平会显著升高，亚低温治疗能降低患者血清中抗脑抗体水平，增加脑血流量。Objective To study the protective effects of mild hypothermia on cerebral and levels of serum levels of anti -brain antibodies after severe traumatic brain injury.Methods Severe traumatic brain injury were selected as the Ⅰ group （n=60）,also select healthy as the Ⅱgroup （n=30）,the Ⅰgroup was divided into group A （n=30）and group B （n=30）according to a random number table.The patients of group A was given hypothermia and the patients of group B were treated with temperature treatment,the levels of anti-brain antibodies in serum of each group were determined in ELISA assay,changes in cerebral blood flow before and after treatment of group A and group B were observed in Doppler,and observed Glasgow Outcome Score （GOS ）of group A and group B.Results The level of anti-brain antibodies in serum of theⅠgroup was （0.59 ±0.02）U/mL significantly higher than that ofⅡ group （0.38 ±0.01）U/mL,the difference was statistically significant（t=9.192,P=0.029）;the level of anti-brain antibodies in serum after treatment of group A was （1.58 ±0.03）U/ml significantly lower than that of group B （1.82 ±0.04）U/mL,the difference was statistically significant（t=10.042,P=0.019）;the average flow velocity, pulse index and GCS score after treatment of group A were （54.20 ±0.23）cm/s,（0.51 ±0.02）,（10.03 ±1.03） points significantly better than those of group B[（40.03 ±0.04）cm/s,（0.72 ±0.02）,（8.12 ±0.02）points],the difference was statistically significant （t=9.892,10.041,9.189,P=0.021,0.018,0.026）.Conclusion The lev-els of anti-brain antibodies in serum can significantly increase after severe traumatic brain injury,Hypothermia can reduce the serum levels of anti-brain antibodies,can increase cerebral blood flow.

关 键 词：颅脑创伤 抗脑抗体 亚低温 

分 类 号：R651.15[医药卫生—外科学]