南天竹提取物对三氧化二砷致肝毒性的保护作用  

Hepatoprotective activity of the extract of Nandina domestica Thunb.against arsenic trioxide induced hepatic injury in rats

作　　者：刘建群[1] 彭财英[1] 舒积成[1] 张锐[1] 任晓静[1] 

机构地区：[1]江西中医药大学,江西南昌330004

出　　处：《时珍国医国药》2015年第4期772-773,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81102788);江西省自然科学基金(No.20114BAB215041)

摘　　要：目的研究南天竹种子提取物对三氧化二砷致肝毒性的保护作用。方法采用三氧化二砷致急性肝损伤模型,比较三氧化二砷单用及与南天竹种子提取物联用对小鼠急性肝毒性、肝组织形态和大鼠肝功能的影响来评价南天竹对三氧化二砷致肝毒性的减毒作用。结果三氧化二砷联用南天竹种子提取物后LD50增大了约50%,肝细胞损伤明显减轻,ALT和AST明显降低。结论联合应用南天竹种子提取物可降低三氧化二砷致肝毒性的毒性。Objective Extract of the fruit of Nandina domestica ThuMb. was screened for hepatoprotective potency against arsenic trioxide induced liver damage in rats. Methods Arsenic trioxide was employed to establish arsenic trioxide - induced acute liver injury mouse models. Toxicity of arsenic trioxide combined with Nandina domestica were evaluated with LD50, morphology of hepatic tissue and liver function. Results The LD50 of arsenic trioxide was significantly increased. Meanwhile, ALT and AST were significantly decreased while combined with Nandina domestica. Conclusion Nandina domestica can reduce the toxicity of arsenic trioxide.

关 键 词：南天竹 三氧化二砷 急性肝损伤 肝保护 

分 类 号：R285.5[医药卫生—中药学]