潜阳育阴颗粒对血管紧张素Ⅱ诱导的人肾系膜细胞增殖的影响  

Effects of Qianyangyuyin Granule on the Proliferation of Human Mesangial Cells stimulated with Angiotensin Ⅱ

作　　者：丁康[1,2] 周建中 张伟 赵庆峰 方祝元 

机构地区：[1]南京中医药大学,江苏南京210023 [2]南京市中医医院,江苏南京210001 [3]江苏省中医医院,江苏南京210029

出　　处：《时珍国医国药》2015年第4期792-794,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81273713)

摘　　要：目的探讨潜阳育阴颗粒对人肾系膜细胞增殖的影响进而寻求其治疗高血压肾损害的机制。方法采用血管紧张素II诱导人肾系膜细胞增殖造模,MTT法研究潜阳育阴颗粒不同浓度对细胞增殖的影响,并计算抑制率。结果潜阳育阴颗粒在一定浓度下均能抑制细胞增殖。结论潜阳育阴颗粒对人肾系膜细胞增殖有明显的抑制作用,为其在治疗高血压肾损害中的作用提供了理论依据。Objective To study the effects of Qianyangyuyin Granule（QYYYG） on the proliferation of Human Mesangial Cells （HMCs） stimulated with Angiotensin II. Methods Study the effect of different density of QYYYG on the proliferation of AngⅡ - induced HMCs by MTT assay, and calculate the inhibitory rate. Results QYYYG could stimulate the cells to reproduce in low density, and had inhibitory activity in some density. Conclusion QYYYG can inhibit proliferation of HMCs, and provide a theoretical basis in the treatment of hypertensive renal damage.

关 键 词：潜阳育阴颗粒 人肾系膜细胞 MTT 细胞增殖 ANGII 

分 类 号：R285.5[医药卫生—中药学]