清血通脉颗粒喷雾制粒工艺的正交试验法优化  

Orthogonal test optimization Qingxue Tongmai particle spray granulating process

作　　者：姜鸿[1] 侯政[1] 李丽 尤献民[1] 赵金明[1] 

机构地区：[1]辽宁省中医药研究院,辽宁沈阳110034 [2]辽宁省锦州市食品药品检验所,121001

出　　处：《时珍国医国药》2015年第4期882-883,共2页Lishizhen Medicine and Materia Medica Research

基　　金：辽宁省科技计划项目(No.2011408004);辽宁省沈阳市科技计划项目(No.F11-154-9-00)

摘　　要：目的优化清血通脉颗粒的最佳喷雾制粒工艺条件。方法采用正交试验法,以颗粒成品率和丹参酮ⅡA转移率为考察指标,对影响清血通脉颗粒喷雾制粒过程的主要因素进行考察。结果最佳工艺参数为：雾化压力0.25MPa,进口温度为95-100℃,出口温度为60-70℃,流浸膏相对密度为1.10（80℃）。结论该工艺条件合理,制出的颗粒质量稳定,为工业化生产提供了实验依据。Objective To optimize Qingxue Tongmai panicle best spray granulating process conditions. Methods Using the orthogonal test method, with grain yield and tanshinone Ⅱ A transfer rate as the inspection indexes, the influence Qiugxue Tongmai particle spray granulating process of the main factors on investigation. Results The best technological parameters： atomization pressure 0.25Mpa, inlet temperature 95 - 100℃, outlet temperature 60 - 70℃, extract relative density 1.10 （ 80℃ ）. Conclusion The process conditions are reasonable, which panicles stable quality, provide and experimental basis for industrial production.

关 键 词：清血通脉颗粒 喷雾制粒 正交试验 丹参酮ⅡA 

分 类 号：R283[医药卫生—中药学]