Ⅱ型糖尿病肾病患者血清尿酸和胱抑素C检测分析  

Serum uric acid and cystatin C in patients with type Ⅱ diabetic nephropathy

作　　者：吕岩[1] 张迎春[1] 赵雪松[1] 高莹[1] 

机构地区：[1]齐齐哈尔医学院第二附属医院检验科,黑龙江齐齐哈尔161000

出　　处：《中国公共卫生》2015年第5期666-668,共3页Chinese Journal of Public Health

摘　　要：目的探讨血清尿酸和血清胱抑素C(Cys-C)检测对评价II型糖尿病及合并肾功能损害的临床意义,并分析其与尿白蛋白排泄率(UAER)的关系。方法收集医院门诊和住院的II型糖尿病患者共253例,将II型糖尿病患者按其是否有肾脏损伤及损伤程度分为3组:单纯糖尿病组,糖尿病早期肾病组和糖尿病临床肾病组,并检测UAER、血清尿酸、Cys-C、血清肌酐(Scr)及尿肌酐,并计算内生肌酐清除率(Ccr)。结果血清尿酸和血清Cys-C随UAER的增加而增加,且差异有统计学意义(P<0.05),此外,各实验室指标性别间差异均有统计学意义(P<0.05);相关性分析结果显示,血清尿酸与UAER呈正相关(r=0.728,P<0.05),Cys-C与UAER也呈正相关(r=0.681,P<0.05)。结论在II型糖尿病肾病患者血清中,血清尿酸和Cys-C均呈现大幅升高的趋势。Objective To explore the clinical significance of serum uric acid and cystatin C（ Cys-C） in patients with type Ⅱ diabetic nephropathy and to analyze its relationship with urinary albumin excretion rate（ UAER）. Methods Totally 253 outpatients and hospitalized patients with type Ⅱ diabetes were recruited in a hospital and all the patients were divided into one of the three（ simple diabetic,early diabetic nephropathy,and clinical diabetic nephropathy） groups according to whether having a kidney damage and its extent; then their UAER,serum uric acid,Cys-C,serum creatinine（ Scr）,and urine creatinine were detected and their creatinine clearance rates（ Ccr） were calculated. Results The serum uric acid and Cys-C increased with the increase of UAER and the difference was statistically significant（ P〈0. 05）. In addition,between-gender differences in all the laboratory indicators were statistically significant（ all P〈0. 05）. Correlation analysis show ed that serum uric acid and Cys-C were positively correlatted with UAER（ r = 0. 728,P〈0. 05 and r = 0. 681,P〈0. 05）. Conclusion Serum uric acid and Cys-C increase significantly in the patients with type Ⅱ diabetic nephropath.

关 键 词：Ⅱ型糖尿病肾病 血清尿酸 胱抑素C 检测指标 

分 类 号：R587.1[医药卫生—内分泌] K587.1[医药卫生—内科学]