2,5-二甲基苯乙酸合成工艺改进研究  

Improvement on Synthetic Method of 2,5-Dimethylphenylacetic Acid

作　　者：邹建平[1,2,3] 尹笃林[1] 赵东江[2,3,4] 陈蒙慈 杨彬[2,3,4] 陈明[2,3] 

机构地区：[1]湖南师范大学化学化工学院,湖南长沙410081 [2]湖南化工研究院国家农药创制工程技术研究中心,湖南长沙410014 [3]农用化学品湖南省重点实验室,湖南长沙410014 [4]湖南大学化学化工学院,湖南长沙410082 [5]湖南海利化工股份有限公司,湖南长沙410007

出　　处：《精细化工中间体》2015年第2期20-22,共3页Fine Chemical Intermediates

摘　　要：以对二甲苯为原料,经氯甲基化、氰化和酸性水解制备2,5-二甲基苯乙酸。通过优化氯甲基化反应的条件,大幅度降低了二取代产物的量;通过氰基酸性水解避免了碱性水解法产品难过滤、含盐废水大的问题。总收率77.9%,含量99%以上。2,5-Dimethylphenylacetic acid was obtianed through a series of reactions including chloromethylation, cyanidation, and acid hydrolysis using para-xylene as the starting material. The content of two substituted impurities was greatly reduced through optimizing the reaction conditions for chloromethylation. The work-up process was greatly improved by the changing the hydrolysis condition from basic to acidic. In this process, the filtration of a large quantity of salinity wastewater was avoided. A total yield of 77.9% with purity over 99% was obtained.

关 键 词：2 5-二甲基苯乙酸 氯甲基化 氰化 酸性水解 

分 类 号：S482.52[农业科学—农药学]