香叶基砜的合成工艺改进  

An Improvement on the Synthetical Process of Geranyl Sulfone

作　　者：焦淑清[1] 陶轶[2] 张萍[1] 白雪彬 李进京[1] 

机构地区：[1]佳木斯大学药学院黑龙江省生物药制剂重点实验室,黑龙江佳木斯154007 [2]齐齐哈尔市第一医院,黑龙江齐齐哈尔161005 [3]佳木斯多多药业有限公司,黑龙江佳木斯154007

出　　处：《精细化工中间体》2015年第2期40-42,共3页Fine Chemical Intermediates

基　　金：黑龙江省教育厅科学技术研究项目(12541819)

摘　　要：以香叶醇为原料,经过溴代和取代2步反应,合成了长链聚异戊二烯类化合物的重要中间体香叶基砜(1)。其结构经MS和1H NMR谱确证。考察了溴代试剂、反应溶剂以及丙烯位砜基化试剂苯亚磺酸钠用量对反应的影响,在改进的工艺条件下2步反应总收率为73.9%。改进的方法反应条件温和、操作简单、收率高,易于工业化生产。The geranyl sulfone, an important intermediate for the preparation of polyisoprenoid compounds, was synthesized by a two-step reaction including bromination and substitution using geraniol as the starting material. The structure was characterized by MS and ^1H NMR. The affecting factors including the bromination agent, reaction solvent and the quantity of sodium benzene sulfinate were evaluated. The overall yield of the two-step reaction was 73.9%. This improved process has the advantages including mild condition, simple operation, high yield and the easier industrialization.

关 键 词：香叶醇 香叶基砜 长链聚异戊二烯类化合物 

分 类 号：TQ227[化学工程—有机化工]