三七乳香合剂镇痛抗炎作用的实验研究  

Experimental study on analgesic and anti-inflammatory effects of SQRXC

作　　者：李光民[1] 储金秀[1] 韩淑英[1] 

机构地区：[1]河北联合大学基础医学院药理学系,河北省唐山市063000

出　　处：《河北医药》2015年第10期1458-1460,共3页Hebei Medical Journal

基　　金：河北省自然基金项目(编号:C2010001795);河北省教育厅青年基金项目(编号:2011156)

摘　　要：目的观察三七乳香合剂(Sanqiruxiang composition,SQRXC)的镇痛抗炎作用。方法 Wistar大鼠,雌雄兼有50只,昆明小鼠,雌雄兼有180只,热板法镇痛实验选取雌性小鼠80只,分为空白对照组、阳性对照药组、SQRXC低剂量组、SQRXC中剂量组和SQRXC高剂量组,观察痛阈值。扭体法镇痛实验,选择小鼠50只,雌性各半,分组同热板法镇痛实验,观察各组潜伏期、扭体次数和镇痛百分率。二甲苯致小鼠耳肿胀抗炎实验,选择小鼠50只,雌雄兼有,分组同热板法镇痛实验,观察小鼠耳肿胀度、肿胀抑制率。角叉菜致大鼠足肿胀抗炎实验,选取大鼠50只,分组同热板法镇痛实验,观察大鼠足掌肿胀度和肿胀抑制率。跌打丸作为阳性对照药物。结果 SQRXC可以显著提高实验小鼠的热痛阈(P<0.05),明显降低小鼠扭体反应次数和扭体反应动物数(P<0.05)。对角叉菜胶所致大鼠足肿胀和二甲苯所致小鼠耳肿胀均有显著抑制作用(P<0.05或<0.01)。结论 SQRXC具有很好的镇痛抗炎作用。Objective To observe the analgesic and anti-inflammatory effects of Sanqiruxiang composition （SQRXC）.Methods Fifty Wistar rats （both males and females）and 180 Kunming mice （both males and females）were enrolled in the study.Hot plate procedure analgesia test：80 female mice were divided into blank control group,positive control group,low-dose SQRXC group,median-dose SQRXC group and high-dose SQRXC group,then the pain threshold value was observed.The writhing body procedure analgesia test：50 mice （25 males and 25 females ）were divided into 5 groups,the grouping was the same as that of hot plate procedure analgesia test,and the latency period,writhing body number of times and analgesia percentage were observed for different groups.The dimethylbenzene-induced ear swelling test：50 mice （both males and females ）were divided into 5 groups,the grouping was the same as that of hot plate procedure analgesia test,and the ear swelling degree,swelling inhibition rate were observed.The anti-inflammatory test in carrageenan-induced foot sole swelling of rats：50 rats were divided into 5 groups,the grouping was the same as that of hot plate procedure analgesia test,the swelling degree of food pad and swelling inhibition rate were observed.Dieda pill was used as positive control drug.Results SQRXC could significantly increase the hot pain threshold of experimental mice （P 〈0.05 ）,and could obviously decrease the frequency of writhing body response and numbers of mice with writhing body response （P 〈0.05）.SQRXC could also inhibit dimethylbenzene-induced ear swelling and carrageenan-induced foot pad swelling （P 〈0.05 or P 〈0.01）.Conclusion SQRXC has obvious analgesic and anti-inflammatory effects.

关 键 词：三七乳香合剂 镇痛 抗炎 

分 类 号：R971.1[医药卫生—药品]