冠心病患者血浆D-二聚体与低密度脂蛋白水平的相关性探讨  

Relationship between D-dimer and low-density lipoprotein level in plasma of patients with coronary heart disease

作　　者：刘艳红[1] 陈进[1] 

机构地区：[1]武汉大学人民医院检验科,湖北武汉430060

出　　处：《海南医学》2015年第8期1115-1117,共3页Hainan Medical Journal

基　　金：国家自然科学基金(编号:81170273)

摘　　要：目的探讨冠心病患者血浆D-二聚体(D-dimer,D-D)与低密度脂蛋白(Low density lipoprotein,LDL)水平之间的关系。方法经心血管造影确诊的冠心病患者150例,平均年龄(63.40±5.70)岁;体检者150例,平均年龄(47.40±7.60)岁;健康志愿者30例,平均年龄(20.30±3.50)岁。SIEMENS ADVIA-2400全自动生化分析仪测定LDL水平,>3.12 mmol/L为阳性;SYSMEX CA7000血凝仪测定D-D水平,>0.6 mg/L为阳性。结果 LDL与D-D水平呈正相关(r=0.237,P<0.05);冠心病组与体检组和健康对照组相比,LDL水平明显升高,差异均具有显著统计学意义(P<0.01);D-D水平同时明显升高(P<0.05)。冠心病患者中LDL水平的阳性率为75.3%;而D-D水平的阳性率为97.3%。体检组中LDL水平的阳性率为18%;LDL阳性体检者中D-D水平的阳性率为48.1%;LDL阴性体检者中D-D水平的阳性率为1.63%。结论 D-D的检测可以提高LDL水平对冠心病预测的准确性。Objective To investigate the relationship between D-D and low-density lipoprotein （LDL） level in plasma of patients with coronary heart disease. Methods One hundred and fifty patients confirmed with coronary heart disease by coronary angiography were enrolled in the study （coronary heart disease group）, with a mean age of （63.40 ±5.70） years old. One hundred and fifty physical examination persons were collected as the physical examination group, with a mean age of （47.40±7.60） years old. Thirty healthy volunteers were enrolled as the healthy control group, with a mean age of （20.30±3.50） years old. The LDL levels were determined by SIEMENS ADVIA-2400 automatic biochemical analyzer, taking〉3.12 mmol/L as positive. The D-D levels were determined by SYSMEX CA7000 blood coagulation analyzer, and〉0.6 mg/L was taken as positive. Results D-D level was positively correlated with LDL （r=0.237, P〈0.05）. The LDL and D-D levels in coronary heart disease group were significantly higher than those in physical examination group and healthy control group （P〈0.05）. The positive rate of LDL levels in coronary heart disease group was 75.3%, and the positive rate of D-D level was 97.3%. The positive rate of LDL level in physical examination group was 18%, and the positive rate of D-D level in LDL-positive individuals in physical examination group was 48.1% and that in LDL-negative individuals was 1.63%. Conclusion The detection of D-D can improve the accuracy of prediction of LDL levels on coronary heart disease.

关 键 词：D-二聚体 低密度脂蛋白 冠心病 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]