1530名儿童抗-HBs定量检测结果研究  

Analysis of Anti-Hepatitis B Surface Antigen Antibody in 1530 Children

作　　者：王勇[1] 邓建军[1] 王利民[1] 何易[1] 胡晓燕[1] 

机构地区：[1]绵阳四O四医院,绵阳621000

出　　处：《成都医学院学报》2015年第2期155-157,共3页Journal of Chengdu Medical College

基　　金：国家"十一五"科技重大专项课题(No:2009ZX10004-905)

摘　　要：目的了解1-15岁儿童乙肝病毒表面抗体（抗-HBs）阳性率,为乙肝疫苗加强免疫提供依据。方法采用双抗原夹心时间分辨免疫荧光分析法对1 530例1-15岁儿童进行抗-HBs检测。结果 1-15岁儿童抗-HBs阳性率为60.26%。其中男性抗-HBs阳性率为55.88%,明显低于女性的64.45%（P〈0.01）;1-6岁年龄组抗-HBs阳性率为64.00%,明显高于7-12岁年龄组的57.48%和13-15岁年龄组的57.14%（P〈0.05）,但7-12岁年龄组与13-15岁年龄组比较差异无统计学意义（P〉0.05）;13-15岁年龄组与7-12岁年龄组和1-6岁年龄组的抗-HBs滴度水平比较,差异均无统计学意义（P〉0.05）。结论本地区儿童抗-HBs阳性率存在人群差异,可能与年龄、性别相关,且随年龄的增长而有所下降。Objective To investigate the positive rate of anti-hepatitis B surface antigen antibody （anti-HBs） in 1-15 years old children and provide the basis of hepatitis B vaccine strengthen immunity. Methods The double antigen sandwich of time-resolved immunofluorometric assay was applied to analyze the concentration of anti-HBs in 1 530 children. Results The positive rate of anti-HBs was 60.26%. The positive rate was 55.88% in male,and the positive rate was 64.45 % in female,there were statistically significant differences between male and female children （P〈0.01）. The positive rate of anti-HBs in 1-6 years old group were higher than 7-12 years old group and 13-15 years old group （P〈0.05）. There were no statistically differences between 13-15 years old group and 7-12 years old group. There was no difference in the titer level of anti-HBs among the three age groups. Conclusion The positive rate of anti-HBs in children may be related to age and gender.

关 键 词：抗-HBS 儿童 年龄 性别 

分 类 号：R512.62[医药卫生—内科学]