成人皮肌炎伴钙质沉积六例临床分析  

The study of clinical manifestations of calcinosis in adult dermatomyositis

作　　者：江薇[1] 章璐[1] 王国春[1] 

机构地区：[1]中日友好医院风湿免疫科,北京100102

出　　处：《临床内科杂志》2015年第4期257-259,共3页Journal of Clinical Internal Medicine

摘　　要：目的：回顾相关文献并研究成人皮肌炎伴钙质沉积的病例特点。方法分析2008年2月～2014年12月我科收治的6例成人皮肌炎合并钙质沉积患者临床特点及治疗随访情况。结果6例患者男性1例，女性5例；皮肌炎平均起病年龄（24±10）岁；出现钙质沉积平均时间（35±36）个月；钙质沉积最常见出现的部位在四肢，其次在躯干和腋窝；3例合并股骨头坏死；1例抗核基质蛋白2（NXP-2）抗体阳性；6例患者均给予帕米膦酸钠治疗，3例治疗有效。结论起病年龄小、病程长、病情反复活动以及抗 NXP-2抗体阳性与皮肌炎钙质沉积有关，帕米膦酸钠治疗有效且无明显不良反应。Objective To review the literature of calcinosis in adult dermatomyositis（DM）and find out the characters of DM.Methods We use the clinical data of 6 patients of calcinosis in adult dermatomyositis diagnosed in our hospital from Feburary,2008 to December,2014.Results Among 6 pa-tients,there were 1 male and 5 female.The mean age of 6 patients diagnosed dermatomyositis was（24 ±10） years and the average time of development of calcium deposition was（35 ±36）months.The most common site of calcium deposition was limbs,followed by trunk and armpits.3 cases complicated with femoral head necrosis and 1 case had nuclear matrix protein 2 （NXP-2）antibody positive.All of them were given pamidronate treatment,3 cases’patients were effectively treated.Conclusion Calcinosis in dermatomyo-sitis associated with earlier year of onset,longer duration,repeated activity of disease and positive NXP-2. Pamidronate is an apparently safe and effective treatment for calcinosis management in adult dermatomyositis.

关 键 词：皮肌炎 钙质沉积 回顾性研究 

分 类 号：R593.26[医药卫生—内科学]