5-HTR1A基因rs6295多态性、负性生活事件与青少年攻击行为的关系  

5-HTR1A Gene Rs6295 Polymorphism, Negative Life Events and Aggressive Behavior

作　　者：王美萍[1] 张文新[1] 

机构地区：[1]山东师范大学心理学院,济南250014

出　　处：《中国临床心理学杂志》2015年第2期206-208,212,共4页Chinese Journal of Clinical Psychology

基　　金：2013年度高等学校博士学科点专项科研基金项目(博导类20133704110001);山东省优秀中青年科学家奖励基金项目(BS2013SF010);山东师范大学发展与教育心理学"十二五"强化建设重点学科建设经费资助项目

摘　　要：目的:考察5-HTR1A基因rs6295多态性、负性生活事件与攻击行为的关系。方法:采用青少年生活事件量表、Achenbach青少年行为自评量表对715名初中生进行测量,并筛选出高、低攻击组被试共153名进行DNA分型。结果:rs6295多态性主效应不显著,负性生活事件可以显著正向预测青少年攻击行为,二者存在交互作用趋势,但未达到显著性水平。结论:负性生活事件是青少年攻击行为的重要影响因素,但其与rs6295多态性的交互效应尚有待进一步验证。Objective： To explore the association among 5-HTR1 A gene rs6295 polymorphism, negative life events and adolescents＇ aggressive behavior. Methods： Adolescent Life Events Scale and Youth Self Report（YSR） were administered to 715 Junior high school students, and 153 participants who scored on the top 10% or at the bottom 10% of aggressive behavior were collected DNA from saliva and genotyped. Results： No significant main effect of rs6295 polymorphism on adolescents＇ aggressive behavior was found. However negative life events could positively and significantly predict adolescents＇ aggressive behavior. There existed an interactive tendency between rs6295 polymorphsim and negative life events,but failed to reach the significant level. Conclusion： Negative life events play an important role in adolescents＇ aggressive behavior, but its interaction effect with rs6295 polymorphsim on aggressive behavior remains to be verified.

关 键 词：5-HT1A基因rs6295多态性 负性生活事件 青少年攻击行为 

分 类 号：R395.1[哲学宗教—心理学]