丁基苯酞对大鼠额叶损伤后学习记忆的影响  

The Effects of Butylphthalide on Learning and Memory Function in Frontal Cortex Injury Rats

作　　者：廖艳彪 李江[1,2] 何骑伟 汤华[4] 胡鹏[4] 彭立辉[1,2] 

机构地区：[1]湖南师范大学第二附属医院 [2]解放军一六三医院神经外科,长沙410003 [3]湖南师范大学第二附属医院心内科,长沙410003 [4]湖南城市学院,益阳413049

出　　处：《中国临床心理学杂志》2015年第2期228-230,200,共4页Chinese Journal of Clinical Psychology

基　　金：湖南省2014年教育厅一般科研项目(14C0704)

摘　　要：目的:研究丁基苯酞对于大鼠额叶损伤后学习记忆功能的影响。方法:选用40只雄性SD大鼠随机分成四组:丁基苯酞组、神经节苷脂组、损伤对照组和假手术组。分组后制作大鼠额叶损伤模型和假手术模型,并予以药物和生理盐水腹腔注射。腹腔注射后进行水迷宫检测、并对大鼠额叶皮层进行SOD(超氧化物歧化酶)、MDA(丙二醛)检测,分析丁基苯酞对额叶损害后大鼠学习记忆功能的影响。结果:与损伤对照组比较,丁基苯酞能够提高额叶损伤后大鼠的水迷宫学习记忆成绩,能够提高损伤区的SOD活性,降低MDA含量,抑制Ach E活性。结论:丁基苯酞能改善大鼠额叶损伤后学习记忆功能,其机制可能与抗氧化和抑制Ach E(乙酰胆碱酯酶)活性有关。Objective： To study the effect of Butylphthalide on learning and memory function of rats after frontal cortexinjury. Methods： Selection of Clean SD rats were divided into four groups were randomly divided into four groups： bu-tylphthalide group, ganglioside group, damage control group and Sham operation group. After grouping to make rat frontalcortex injury model and sham operation model. And to give drugs and intraperitoneal injection of saline solution.Analysis ofthe effect of butylphthalide on learning and memory function of rats after frontal cortex injury through the water maze test,superoxida superoxide dismutase（SOD） examination, Malondialdehyde（MDA） examination. Results： Butylphthalide can Im-prove the water maze test after frontal cortex injury in rats, can improve the damage zone SOD activity, decreased the con-tent of MDA, inhibiting the activity of Ach E. Conclusion： Butylphthalide can improve learning and memory function afterfrontal cortex injury in rats, its mechanism may be related with antioxidation and inhibit the activity of Ach E.

关 键 词：额叶损伤 学习记忆功能 丁基苯酞 

分 类 号：R395.1[哲学宗教—心理学]