Glass capillary nanopore for single molecule detection  

作　　者：SHA JingJie SI Wei XU Wei ZOU YiRen CHEN YunFei 

机构地区：[1]Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University [2]School of Mechanical Engineering, Southeast University

出　　处：《Science China(Technological Sciences)》2015年第5期803-812,共10页中国科学（技术科学英文版）

基　　金：supported by the National Basic Research Program of China("973"Project)(Grant No.2011CB707605);National Natural Science Foundation of China(Grant No.51375092);the support by the Fundamental Research Funds for the Central Universities(Grant No.2242015R30002);supported by the Fundamental Research Funds for the Central Universities and the Innovative Project for Graduate Students of Jiangsu Province(Grant No.KYLX_0100)

摘　　要：Single molecule detection based on nanopore technology is a very promising approach for medical diagnostics, drug therapy and even DNA sequencing. Compared with other biological nanopores and solid-state nanopores, the glass capillary nanopore has low cost, easy availability and stable mechanical characteristics, thus it has been widely used in the nanopore technology for single molecule detection. In this review, we will focus on the studies of the glass nanopore sensors. The popular glass nanopore fabrication methods would be introduced, and the applications of glass nanopores in the detection of nanoparticles, proteins and DNA molecules would be presented. We hope this review will help widen field of vision and promote the development of the nanopore technology based on the glass capillary nanopores.

关 键 词：fabrication capillary nanotubes sequencing diameters SWNTs DNA etching diagnostics nanometer 

分 类 号：Q-3[生物学] TB383.1[一般工业技术—材料科学与工程]