D-二聚体水平变化与类风湿关节炎病情活动性的相关性分析  

Correlation analysis between D-dimer level changes and rheumatoid arthritis(RA) disease activity

作　　者：张竹青[1] 朱芸[2] 张滨[2] 马晶晶[2] 昌路艳 

机构地区：[1]潍坊医学院内科学教研室 [2]潍坊医学院附属潍坊市人民医院风湿免疫科,山东潍坊261053

出　　处：《中国现代医生》2015年第12期48-50,共3页China Modern Doctor

摘　　要：目的探讨类风湿关节炎(RA)患者中血浆D-二聚体(D-D)水平变化,并分析其与各临床指标的关系。方法检测138例RA患者和47例正常对照组患者血浆D-二聚体水平,分析其与年龄、类风湿因子(RF)、红细胞沉降率(ESR)、视觉模拟评分(VAS评分)、血小板的相关性。结果 RA组血浆D-二聚体水平明显高于健康对照组,差异有统计学意义(P<0.01);病情高活动组、病情低活动组RA患者D-二聚体水平明显高于病情缓解组RA患者(P均<0.01);病情高活动组RA患者D-二聚体水平明显高于病情低活动组(P<0.01);所有RA患者D-二聚体水平与年龄、ESR、VAS评分、RF、血小板均呈明显正相关(P均<0.01)。结论 RA患者体内存在高凝状态,D-二聚体可作为临床判断RA患者病情活动的非特异性炎性反应指标,亦可指导临床治疗。Objective To study the plasma D-dimer （DD） level changes in the patients with rheumatoid arthritis （RA）, and to analyze its correlation with various clinical indicators. Methods Selected a total of 138 cases of RA patients and 50 cases of normal person as matched group the plasma D-dimer level and the correlation analysis with age, rheuma-toid factor （RF）, erythrocyte sedimentation rate （ESR）, visual analogue scale （VAS score）and platelet were analyzed. Results The level of D-dimer level in RA patients was significantly higher than that of healthy controls, and the dif-ference was statistically significant （P〈0.01）;The D-dimer level of high disease activity group and low disease activity group with RA patients were significantly higher than the remission groups of RA patients （P all 〈0.01）; The D-dimer level in high disease activity group of RA patients was significantly higher than the low disease activity group （P〈0.01）; There were positive correlations between the D-dimer level and the age, ESR, VAS score, RF, platelet in all RA patients （P all 〈0.01）. Conclusion There is high coagulation state in RA patients, so the D-dimer can be used as a clinical nonspecific inflammatory reaction index in patients with RA, and can direct the clinical treatment.

关 键 词：类风湿关节炎 D-二聚体 VAS评分 红细胞沉降率 类风湿因子 

分 类 号：R593.22[医药卫生—内科学]