黄芩苦参合剂雾化吸入预防化疗后下呼吸道感染并发侵袭性真菌感染的临床研究  

Clinical study of atomization inhalation with mixture of baikal skullcap root and lightyellow sophora root for proventing invasive fungal infections on lower respiratory tract infection after chemotherapy

作　　者：方群[1] 高祥福[2] 毛向红[3] 楼黎明[4] 章玲玲[1] 陈福兰[4] 林敏[5] 陈晓明[6] 

机构地区：[1]浙江中医药大学附属第三医院院感科,浙江杭州310005 [2]浙江中医药大学附属第三医院中医科,浙江杭州310005 [3]浙江中医药大学附属第三医院检验科,浙江杭州310005 [4]浙江中医药大学附属第三医院呼吸科,浙江杭州310005 [5]浙江中医药大学附属第三医院放射科,浙江杭州310005 [6]浙江中医药大学附属第三医院设备科,浙江杭州310005

出　　处：《中国现代医生》2015年第12期102-105,共4页China Modern Doctor

基　　金：浙江省中医药科学研究基金计划(2013ZB074)

摘　　要：目的探讨黄芩苦参合剂雾化吸入对化疗后下呼吸道院内感染患者并发侵袭性肺部真菌感染的预防作用。方法选择60例肿瘤化疗后下呼吸道院内感染老年患者,随机分为对照组及治疗组,每组30例,所有患者均依据药敏结果抗感染治疗,治疗组患者另给予黄芩苦参合剂雾化吸入每日2次,2周后比较两组患者临床治疗效果,观察两组肺部真菌感染发生率及发生时间,比较两组患者治疗前后血气分析情况。结果治疗组临床有效率86.67%,对照组临床有效率70.00%,治疗组临床有效率高于对照组;治疗组肺部真菌感染率6.67%,对照组肺部真菌感染率23.33%,治疗组真菌感染率低于对照组;治疗组真菌感染时间(11.58±1.3)d,对照组真菌感染时间(9.41±1.10)d,治疗组真菌感染时间迟于对照组;两组患者治疗前血气分析p H、Sa O2、Pa CO2、Pa O2水平无显著差异,治疗2周后治疗组p H、Sa O2、Pa O2水平高于对照组,Pa CO2水平低于对照组。结论黄芩苦参合剂雾化吸入能够改善化疗后下呼吸道院感老年患者的临床疗效,改善呼吸功能,预防继发侵袭性肺部真菌感染,具有较好的临床效果。Objective To investigate the preventive effect of atomization inhalation with mixture of baikal skullcap root and light yellow sophora root for proventing invasive fungal infection on lower respiratory tract infection after chemotherapy. Methods A total of 60 cases of patients with lower respiratory tract infections after chemotherapy were selected and randomized into control groups and treatment groups, there were 30 cases in every group, anti-infection was taken in two groups according to drug sensitivity test,atomamdation inhalation with mixture of baikal skullcap root and light yellow sophora root was taken in treatment groups in addition, clinical effect was contrasted, incidence rate and time of fungal infection were contrasted between control group and treatment group,and index of blood gas analysis was contrasted between control group and treatment group after two weeks. Results Clinical efficiency was 86.67% in treatment group and was 70.00% in control group,clinical efficiency was higher in treatment groups than in control group,incidence rate of fungal infection was 6.67% in treatment group and was 23.33% in control group,incidence rate＆nbsp;of fungal infection was lower in treatment group than in control goup,time of fungal infection was （11.58±1.31）days in treatment group and was （9.41±1.10）days in control group,time of fungal infect was later in treatment group than that in control group. There were no significant differences of the levels of pH,SaO2,PaCO2 and PaO2 between the two groups before treatment, the levels of pH,SaO2,and PaO2 were higher and PaCO2 was lower in treatment group than that in control goup after treatment. Conclusion Atomization inhalation with mixture of baikal skullcap root and light yellow sophora root could improve clinical curative effect of lower respiratory tract infection after chemotherapy,and im-prove respiratory function,provent invasive fungal infections and has good clinical effect.

关 键 词：真菌感染 呼吸道感染 黄芩苦参合剂 院内感染 老年人 

分 类 号：R272[医药卫生—中医儿科学]