维生素D与胰岛细胞功能关系的研究进展  

Advanced on the relationship between vitamin D and islets function

作　　者：钟丽娣 池莲祥[2] 聂雷[3] 聂本遂[4] 万杰君 

机构地区：[1]广东医学院 [2]深圳市宝安人民医院内分泌科,广东深圳518101 [3]深圳市南山区人民医院内分泌科,广东深圳518000 [4]深圳市宝安人民医院普外科,广东深圳518101 [5]广东省东莞市太平人民医院内分泌科,广东东莞523900

出　　处：《中国现代医生》2015年第12期157-160,共4页China Modern Doctor

摘　　要：维生素D是经典的钙磷代谢调节剂。胰岛素抵抗与胰岛β细胞功能受损引起胰岛素分泌缺陷和合成异常是2型糖尿病发病机制的主要特点。近年来国内外越来越多的研究表明,维生素D与2型糖尿病之间关系密切;许多基础研究和动物实验显示维生素D在糖尿病的发生发展过程中发挥着改善胰岛素抵抗、保护胰岛细胞以及调节人体免疫功能的作用。维生素D主要可通过以下3种方式来调控胰岛功能:抑制胰岛β细胞凋亡、促进胰岛β细胞分泌和削弱胰岛α细胞分泌。本篇文章就近年来维生素D与胰岛β细胞功能的相关性研究方面作一综述。Vitamin D is classic metabolism regulator of the calcium and phosphorus. Type 2 diabetes is main charac-terized by insulin resistance and beta cell function impairment, which causes insulin secretion defects and synthesis ab-normality. In recent years, studies found close relationship between vitamin D and type 2 diabetes; Many basic re-searches and animal experiments show that vitamin D can improve insulin resistance, protect islet beta cells and have immune regulation effects in the development of type 2 diabetes Diseases. Vitamin D can regulate and control islet function by inhibiting islet beta cell apoptosis, promoting the secretion of pancreatic beta cells and weakening the se-cretion of islet alpha cell. This paper reviewed the research progress in recent years on the correlation between vitamin D and islets function.

关 键 词：维生素D 维生素D受体 2型糖尿病 胰岛细胞功能 

分 类 号：R587.1[医药卫生—内分泌]