益气温阳活血中药干预慢性阻塞性肺疾病肺动脉高压机理探讨  

Good Temperature Yang Qi and Chinese Medicine Intervention in Chronic Obstructive Pulmonary Disease Mechanism of Pulmonary Hypertension

作　　者：曲妮妮[1] 刘浩[1] 马丽佳[1] 赵克明[1] 郑忻[1] 束沛[1] 

机构地区：[1]辽宁中医药大学附属医院呼吸科,辽宁沈阳110032

出　　处：《中华中医药学刊》2015年第5期1218-1220,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：沈阳市科技局计划项目(F12-277-1-76)

摘　　要：目的:探讨益气温阳活血中药对慢性阻塞性肺疾病肺动脉高压改善的机制。方法:随机纳入120例慢性阻塞性肺疾病患者作为研究对象,分为治疗组、对照组各60例。对照组予常规治疗基础上加中药安慰剂,治疗组予常规治疗加益气温阳活血中药,疗程2周。以VEGF、TGF-β1以及VEGF、TGF-β1与肺动脉压相关性为观察指标。结果:结合本研究显示:VEGF、TGF-β1,肺动脉压方面,两组相比,差异具有统计学意义(P<0.05);经多元相关性显示,VEGF、TGF-β1与肺动脉压存在相关关系,为正相关关系。结论:益气温阳活血中药可以抑制TGF-β1及VEGF的表达,抑制肺血管的重塑,从而降低慢性阻塞性肺疾病肺动脉高压,改善COPD患者肺动脉高压的恢复及预后,值得在临床中推广应用。Objective ：To explore good temperature Yang qi and Chinese medicine for chronic obstructive pulmonary disease, pulmonary hypertension to improve mechanisms. Methods ： Randomly assigned 120 patients with chronic obstruc- tive pulmonary disease as the research object, divided into the treatment group and control group （n = 60）. The placebo control group in the conventional treatment based upon Chinese traditional medicine, the treatment group in the conven- tional treatment jiayi temperature Yang invigorate the circulation of Chinese traditional medicine, treatment course 2 weeks. With VEGF, TGF - beta 1 and VEGF, TGF - beta 1 to observe correlation with pulmonary artery pressure indica- tors. Results ： Combined with this research shows that ： VEGF, TGF - beta 1, pulmonary artery pressure, statistically sig- nificant difference, compared the two groups （P 〈 0.05 ） ; By multivariate correlation showed that VEGF, TGF - beta 1 was correlated with pulmonary artery pressure, as a positive correlation. Conclusions： Good temperature Yang qi and Chi- nese traditional medicine can inhibit the TGF - beta 1 and the expression of VEGF, inhibition of pulmonary vascular re- modeling, reducing chronic obstructive puhnonary disease, pulmonary hypertension, improve the recovery and prognosis of COPD patients with pulmonary hypertension, is worth popularizing in clinical application.

关 键 词：肺动脉高压 血管内皮生长因子 转化生长因子 

分 类 号：R563[医药卫生—呼吸系统]