儿童原发性肾病综合征血脂变化及瘦素、脂联素水平的研究  

The study of serum lipid changes and levels of leptin and adiponectin in children with primary nephrotic syndrome

作　　者：涂娟[1] 陈朝英[1] 曹力[1] 陈大坤[1] 初梅[1] 耿海云[1] 李华荣[1] 

机构地区：[1]首都儿科研究所附属儿童医院肾内科,北京100020

出　　处：《中国医刊》2015年第4期69-72,共4页Chinese Journal of Medicine

摘　　要：目的了解原发性肾病综合征(primary nephritic syndrome,PNS)患儿血脂变化及其影响。方法测定PNS病例组患儿急性期血脂及瘦素、脂联素水平,并与正常对照相比较。结果 PNS患儿急性期血清脂联素水平较正常对照升高,并与甘油三酯(triglyceride,TG)、低密度脂蛋白(low density lipoprotein,LDL)呈正相关,而血清游离瘦素指数(free leptin index,FLI)较正常对照下降。当激素减量至平台期时体重仍达超重肥胖水平的PNS患儿,其急性期血总胆固醇(total cholesterol,TC)水平较体重正常组升高。结论 PNS患儿急性期的高脂血症伴有血脂联素的升高和FLI的下降,其血TC水平对患儿病程中体重变化有一定影响。Objective To study the serum lipid changes and the effects in children with primary nephritic syndrome （ PNS） . Method Serum levels of lipid, leptin and adiponectin levels were measured in the acute phase of PNS and compared with the control group. Result Serum levels of total cholesterol （ TC） , triglyceride （ TG） and low density lipoprotein （ LDL） were significantly higher in the acute phase of PNS than in the controls and were negatively corre-lated with albumin levels. Serum adiponectin levels were significantly higher in the acute phase of PNS than in the controls and were positively correlated with TG and LDL. Serum free leptin index（FLI） levels were significantly lower than those in the controls. Serum TC levels were significantly higher in the children with PNS who were still of overweight in the plateau phase of steroid than in those of normal weight during the acute phase. Conclusion There is an increase in serum adiponectin and a decrease in FLI when hyperlipemia occurred in children with PNS during the acute period. Serum cholesterol levels have an impact on the weight changes in children with PNS.

关 键 词：原发性肾病综合征 高脂血症 瘦素 脂联素 

分 类 号：R725.9[医药卫生—儿科]