N-乙酰半胱氨酸治疗COPD急性加重期临床疗效分析  

Clinical effect analysis of N-acetylcysteine in the treatment of acute exacerbation of COPD

作　　者：王雯 

机构地区：[1]红河州第一人民医院呼吸内科,661199

出　　处：《中国实用医药》2015年第8期40-41,共2页China Practical Medicine

摘　　要：目的观察雾化吸入N-乙酰半胱氨酸(NAC)在慢性阻塞性肺疾病(COPD)急性加重期的临床疗效。方法 86例COPD急性加重期患者随机分为治疗组44例和对照组42例,两组患者均给予常规基础治疗,治疗组在此基础上加用N-乙酰半胱氨酸雾化吸入,0.3 g/次,2次/d,治疗14 d后比较两组疗效、动脉血氧分压(Pa O2)、动脉血二氧化碳分压(Pa CO2)以及肺功能。结果治疗组和对照组临床总有效率分别为95.5%、76.2%,两组比较差异有统计学意义(P<0.05),且治疗组较对照组肺功能、Pa O2、Pa CO2明显改善(P<0.05)。结论 NAC能显著改善COPD急性加重期疗效,改善Pa O2、Pa CO2以及肺功能。Objective To observe the clinical effect of N-acetylcysteine（NAC） by aerosol inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods A total of 86 patients with acute exacerbation of COPD were randomly divided into treatment group with 44 cases and control group with 42 cases. Both groups received conventional treatment, and the treatment group received additional NAC by aerosol inhalation as 0.3 g/time for 2 times/d. After 14 d of treatment, comparisons were made on curative effects, arterial partial pressure of oxygen（Pa O2）, arterial partial pressure of carbon dioxide（Pa CO2）, and pulmonary function between the two groups. Results The clinical total effective rates of the treatment group and the control group were respectively 95.5% and 76.2%. The difference between the two groups had statistical significance（P〈0.05）. The treatment group had more obvious improvement in pulmonary function, Pa O2, and Pa CO2 than the control group（P〈0.05）. Conclusion NAC can remarkably improve the curative effect on acute exacerbation of COPD, Pa O2, Pa CO2, and pulmonary function.

关 键 词：N-乙酰半胱氨酸 慢性阻塞性肺疾病 疗效 

分 类 号：R563.9[医药卫生—呼吸系统]