氟哌啶醇治疗外伤后急性弥漫性脑肿胀患者的疗效和安全性分析  

Efficacy and safety of haloperidol in the treatment of patients with posttraumatic acute diffuse brain swelling

作　　者：陈映曼[1] 郭静芳[1] 陈伟强[2] 

机构地区：[1]广东省汕头大学医学院第一附属医院产科,汕头515000 [2]广东省汕头大学医学院第一附属医院脑外科,汕头515000

出　　处：《上海医药》2015年第9期28-30,共3页Shanghai Medical & Pharmaceutical Journal

基　　金：汕头市科技计划项目(项目编号:汕府科【2014】62号)

摘　　要：目的:观察氟哌啶醇治疗外伤后急性弥漫性脑肿胀(PADBS)患者的疗效和安全性。方法:选取2012年7月至2014年3月期间我院确诊治疗的PADBS患者136例,随机分为对照组和观察组各68例,两组患者均给予手术、亚低温等常规治疗,观察组在此基础上给予氟哌啶醇治疗,统计分析所有患者平均动脉压(MAP)、心率(HR)和不良反应发生情况,采用蒙特利尔认知评估(Mo CA)量表评估患者认知功能。结果:观察组治疗有效率明显高于对照组;MAP、HR、Mo CA得分明显优于对照组,差异均有统计学意义。观察组患者不良反应发生比例高于对照组,但差异无统计学意义。结论:氟哌啶醇治疗可有效提高外伤后PADBS患者的疗效,有利于改善患者预后,且无明显增加患者不良反应的风险。Objective： To investigate the efficacy and safety of haloperidol in the treatment of patients with posttraumatic acute diffuse brain swelling （PADBS）. Methods： One hundred and thirty-six patients with PADBS in our hospital were randomly divided into a control group and an observation group with 68 cases each. Conventional treatments including operation and hypothermia treatment were given in two groups, and in addition, haloperidol was given in the observation group. Mean arterial pressure （MAP）, heart rate （HR） and adverse reactions of all the patients were analyzed. Montreal cognitive assessment （MoCA） scale was used to assess the cognitive function of the patients. Results： The treatment efficiency of the observation group was higher than that of the control group, and the MAP, HR, MoCA scale were also better in the observation group than in the control group. All the differences are statistically significant. The incidence of adverse reaction was higher in the observation group than in the control group, however there was no statistical significance in differences. Conclusion： Haloperidol can effectively improve the efficacy of patients with PADBS, and is of benefit to the prognosis of patients without significant risk of increasing adverse reactions.

关 键 词：氟哌啶醇 外伤后急性弥漫性脑肿胀 平均动脉压 心率 不良反应 蒙特利尔认知评估量表 

分 类 号：R651.15[医药卫生—外科学]