肿瘤穿膜肽iRGD在肿瘤治疗中的应用研究  

The Application of Tumor-penetrating Peptide iRGD in Cancer Therapy

作　　者：丁岩[1] 彭文毓 吕尚伟[1] 马建岗[1] 卢晓云[1] 

机构地区：[1]西安交通大学生命科学与技术学院生物医学信息工程教育部重点实验室,陕西西安710049

出　　处：《生物工程前沿（中英文版）》2015年第1期15-20,共6页Biotechnology Frontier

基　　金：国家自然科学基金项目（No.81172170,81371288）,陕西省科学技术研究发展计划项目（2013KW32.04）

摘　　要：抗肿瘤药物因难以渗透到实体瘤组织内部而严重影响了治疗效果。KazukiN等在2010年的Science上报道了肿瘤穿膜肽iRGD能够明显改善化疗药物在肿瘤组织中的渗透能力，提高药物疗效，由此引发了人们的广泛关注。本文就近年来应用iRGD进行肿瘤治疗方面取得的相关研究进展进行综述，主要介绍抗癌药物或递送系统经过iRGD的修饰或与iRGD协同注射在肿瘤治疗及成像方面的具体研究进展。这些研究结果显示肿瘤穿膜肽在提高肿瘤治疗效果方面有着良好的应用前景。The poor penetration of anti-cancer drugs into solid tumors tissue decreased the effect of chemotherapy seriously. In 2010, Kazuki N. reported in Science that coadministration of a tumor-penetrating peptide, iRGD could increase tumor vascular and tissue permeability, enhance the efficacy of anti-cancer drugs and improve the therapeutic index of drugs. The effectiveness of iRGD has drawn extensive attention since then. In this paper, we reviewed the recent progress in iRGD-based tumor intervention either by coadministration of iRGD with chemotherapy drugs or by iRGD modified drug delivery system, introduced the specific application in cancer therapy and tumor tissue imaging, and prospected its further application

关 键 词：肿瘤穿膜肽 iRGD 肿瘤治疗 

分 类 号：Q[生物学]