谷胱甘肽在预防呼吸机相关性肺损伤中的作用机制分析  

The mechanism of Glutathione in the prevention of ventilator -associated lung injury

作　　者：孔令贵[1] 文辉[1] 杜宝青[1] 宋淑玲[1] 赵猛[1] 

机构地区：[1]滨州市中心医院ICU,山东省滨州251700

出　　处：《中国基层医药》2015年第8期1125-1126,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨谷胱甘肽在预防呼吸机相关性肺损伤（VALI ）中的作用机制。方法随机选择60例既往体健的机械通气患者，将所有患者按照随机数字表法分为两组，A 组为大潮气量组，潮气量为10 mL／kg，B组为大潮气量外加应用谷胱甘肽2．4 g／d的干预组，48 h后对两组患者肺泡灌洗液进行收集，应用考马斯亮蓝技术的原理测定两组患者支气管肺泡灌洗液中蛋白的含量。结果两组患者的支气管肺泡灌洗液中的蛋白含量明显不同，A组的蛋白含量[（9．90±2．25）g／L]比B组[（4．17±0．39）g／L]明显高，差异有统计学意义（P＜0．01）。结论谷胱甘肽可以降低VALI的发生率，应用谷胱甘肽可以预防呼吸机相关性肺损伤的发生。Objective To investigate the mechanism of Glutathione in the prevention of ventilator-associated lung injury.Methods 30 mechanical ventilation patients who were healthy before were selected and randomly divided into the two groups.Group A was the high tidal volume group：10mL/kg;group B was used the tidal volume plus the injection of Glutathione（2.4g/d）.After 48 hours,we collected lavage fluid and use Coomassie brilliant blue to detect the protein content of alveolar lavage fluid of the two groups.Results There was a significant difference （P〈0.01）between the two groups.The protein content in group A[（9.90 ±2.25）g/L]was higher than that of group B [（4.17 ±0.39）g/L],and there was statistically significant （P〈0.01）.Conclusion Glutathione can reduce the incidence of ventilator-associated lung injury and prevent the occurrence of ventilator-associated lung injury.

关 键 词：谷胱甘肽 呼吸机相关性肺损伤 机械通气 

分 类 号：R563.8[医药卫生—呼吸系统]