血清药理学研究概要  

Methodological Overview of Serum Pharmacology

作　　者：邢作英[1] 王永霞[1] 曹英杰[1] 朱明军[1] 王幼平[1] 高原[1] 

机构地区：[1]河南中医学院第一附属医院,郑州450000

出　　处：《世界科学技术-中医药现代化》2015年第1期219-222,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委青年基金项目(81102698):桂枝甘草汤抗心律失常电生理机制研究;负责人:王永霞;河南省科技厅科技创新杰出青年基金项目(124200510008):交泰丸抗心律失常电生理机制研究;负责人:王永霞;河南省教育厅自然基金项目(2008A360032):基于膜片钳技术的治心悸经方对心肌细胞电生理特性的影响;负责人:朱初麟

摘　　要：中药复方复杂多样,在研究其药理机制过程中暴露出许多问题,在此基础上产生了中药血清药理学。血清药理学是指用含有药物成分的血清施加于体外实验反应体系的一种半体内实验方法,目前正趋于成熟,并广泛应用于对中药复方药理作用和作用机理的研究。中国血清药理学起步晚,缺乏经验,中药血清药理学作为一种新的药理实验方法,在药理机制研究中的应用有待规范化。本文就中药血清药理学的一般方法、研究应用现状、优势和不足,结合笔者在实验中的经验做一概述。Many problems were exposed in the process of research phase of pharmacological mechanism because that traditional Chinese medicine （TCM） compound was complex and diverse based on TCM serum pharmacology production. Serum pharmacology was an ex vivo experimental methodology, in which active serum sampled from laboratory animals after administration with TCM ingredients. Then, it was applied in the bioassay instead of crude extracts from raw ingredients. It was established and well-developed. And now it had been widely tailored into a range of TCM scientific researches, with particular regard to pharmacological properties and mechanisms of action. Serum pharmacology in China started late and lack of experience. TCM serum pharmacology, which was a new pharmacological experiment method, needed to be standardized. In this article, the overall methodology was briefed, along with its recent applications, advantages, disadvantages and perspectives.

关 键 词：中药 血清药理学 方法学 展望 

分 类 号：R285[医药卫生—中药学]