基于ICP-MS法的散结镇痛胶囊中18种重金属及微量元素分析  

Analysis of 18 Types of Heavy Metals and Trace Elements in San-Jie Zhen-Tong Capsule by ICP-MS

作　　者：徐海娟[1,2] 秦建平[1,2] 王金玲[1,2] 李家春[1,2] 吴建雄[1,2] 黄文哲[1,2] 王振中[1,2] 萧伟[1,2] 

机构地区：[1]江苏康缘药业股份有限公司,连云港222001 [2]中药制药过程新技术国家重点实验室,连云港222001

出　　处：《世界科学技术-中医药现代化》2015年第1期278-282,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家重大新药创制项目(2011ZX09201-201-20):子宫内膜异位症首选用药-散结镇痛胶囊大品种技术改造;负责人:荣根新

摘　　要：目的:使用电感耦合等离子质谱仪,建立散结镇痛胶囊中Li、Be、V、Cr、Co、Ni、Cu、Ga、As、Sr、Cd、Sn、Sb、Ba、Hg、Tl、Pb和Bi共18种重金属及微量元素的测定方法。方法:散结镇痛胶囊经微波消解后,以Ge、In为内标,以灌木枝叶标准药材作为质控标准物质,用ICP-MS进行测定。结果:各元素的检出限在0.002 8-0.54μg·L-1之间,回收率在82.8%-107.2%之间,RSD≤5.6%。结论:该方法快速、简便、准确,可以用于散结镇痛胶囊中重金属及微量元素的质量控制。This study was aimed to establish a method for the simuhaneous analysis of 18 types of heavy metals and trace elements in San-Jie ZherL-Tong （SJZT） Capsule, including Li, Be, V, Cr, Co, Ni, Cu, Ga, As, St, Cd, Sn, Sb, Ba, Hg, Tl, Pb and Bi. Samples of SJZT Capsule were digested via microwave. Ge and In were used as internal standard elements. Bush branches and leaves were used as controlled reference standard. ICP-MS was used for the determination. The results showed that the detection limits of all elements were in the range of 0.002 8-0.54 μg· L^-1. with the recovery ranging from 82.8% to 107.2%, RSD ≤ 5.6%. It was concluded that the method was quick, simple and accurate. It can be used for the quality control of heavy metals and trace elements in SJZT Capsule.

关 键 词：散结镇痛胶囊 重金属及微量元素 ICP-MS 微波消解 

分 类 号：R284.1[医药卫生—中药学]