异基因造血干细胞移植后急性移植物抗宿主病患者的护理  

Nursing of patients with acute hepatic graft versus host disease after allogeneic hematopoietic stem cell transplantation

作　　者：周瑾[1] 吴斌[2] 张友山[1] 

机构地区：[1]荆州市第一人民医院慈济分院血液科,湖北荆州434000 [2]荆州市第一人民医院慈济分院风湿科,湖北荆州434000

出　　处：《现代临床护理》2015年第2期21-24,共4页Modern Clinical Nursing

摘　　要：目的：探讨异基因造血干细胞移植（allogeneic hemapoieticstem cell transplantation， allo－HSCT）后急性移植物抗宿主病（acute graft versus host disease， aGVHD）的护理方法。方法回顾性分析2010年1月～2013年12月54例在本院异基因造血干细胞移植后出现移植物抗宿主病患者的临床资料并总结护理方法。结果160例异基因造血干细胞移植患者出现aGVHD 54例，其中Ⅳ度2例，Ⅲ度10例，Ⅱ度23例，Ⅰ度19例。经个体化治疗与护理后，47例（87．01％）治愈，3例（5．56％）转为cGVHD（chronic GVHD），4例（7．41％）死亡。结论加强肝脏、肠道及皮肤的症状观察及护理，同时加强心理护理、饮食护理及全环境保护，是促进aGVHD患者恢复的有效方法。Objective To explore the measures for nursing patients with acute hepatic graft versus host disease （aGVHD） after allogeneic hematopoietic stem cell transplantation. Method The clinical data of 54 patients with aGVHD after hematopoietic stem cell transplantation during January 2010 and December 2013 were reviewed for summing up the nursing measures. Results In the study, 160 patients underwent allogeneic-hematopoietic stem cell transplantation and 53 of them contracted with acute hepatic-versus-host disease. Among them, 2 cases were at degreeⅣ, 10 at degreeⅢ, 23 at degreeⅡand 19 at degreeⅠ. Forty-seven cases（87.01%） were cured after careful treatment and care , 3 （ 5 . 56%） developed into cGVHD and 4 （ 7 . 41%） died . Conclusion Enhanced observation and postoperative nursing of liver, intestine and skin together with performance of mental care and dietary nursing are effective in achieving satisfactory outcomes of GVHD.

关 键 词：造血干细胞移植 急性移植物抗宿主病 护理 

分 类 号：R473[医药卫生—护理学]