α桉醇光敏氧化及抗肿瘤活性研究  

Photosensitized Oxidation of α-eudesmol and Antitumor Researches of the Products

作　　者：赵映梅 张滢[2] 邹澄[2] 曹青青[3] 赵庆[3] 

机构地区：[1]昆明市呈贡区人民医院,云南昆明650500 [2]昆明医科大学,云南昆明650500 [3]云南中医学院,云南昆明650500

出　　处：《云南中医学院学报》2015年第2期18-20,共3页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81460533;81060262)

摘　　要：目的以倍半萜成分进行衍生化以制备具有生物活性的衍生物。方法对α桉醇进行光敏氧化,制备具有抗肿瘤活性的倍半萜衍生物。结果α桉醇的光敏氧化共得到三个倍半萜衍生物,其中一个过氧化产物具有显著的抗肿瘤活性。结论以倍半萜成分为原料,制备具有显著抗肿瘤活性成分是可行的。Objective Sesquiterpenoids were utilized to synthesis bioactive derivatives. Methods α-eudesmol, a sesquiterpene, was oxidized with the method of photosensitized oxidation. Results Three sesquiterpene derivatives were obtained, one peroxide derivative showed significant antitumor activity against several cancer cells. Conclusion It is feasible to obtain the derivatives with significant antitumor activity.

关 键 词：α桉醇 光敏氧化 抗肿瘤活性 倍半萜类 姜科植物 滇姜花 

分 类 号：R284[医药卫生—中药学]