外周5-羟色胺在胰岛素抵抗中的作用研究进展  

Research Progress in the Role of Peripheral 5- hydroxytryptamine in Insulin Resistance

作　　者：李涛[1] 傅继华[1] 王天莹 

机构地区：[1]中国药科大学药学院生理教研室,江苏南京210009 [2]中国药科大学药学院,江苏南京211198

出　　处：《药学进展》2015年第2期113-118,共6页Progress in Pharmaceutical Sciences

基　　金：中国药科大学大学生创新训练计划项目(No.J1030830)

摘　　要：5-羟色胺(5-HT)作为一种神经递质在中枢神经系统中具有重要的作用,同时在外周组织系统中5-HT也发挥多种重要的生物功能,如广泛参与机体的糖脂代谢、肝再生、胃肠运动等。综述外周5-HT诱导胰岛素抵抗的作用机制研究新进展,重点介绍5-HT对胰岛素信号转导、糖脂代谢等方面的影响。5-hydroxytryptamine （5-HT） is a neurotransmitter with important functions in the central nervous system. Besides, it is implicated in a vast array of physiological activities in peripheral tissues including glucose and lipid metabolism, liver regeneration, gastrointestinal motility, etc. The latest research achievements on the role of peripheral 5-HT in insulin resistance （IR） were reviewed in this article, which mainly focused on the involvement of 5-HT on insulin signal transduction, glucose and lipid metabolism during IR status.

关 键 词：5-羟色胺 胰岛素抵抗 信号转导 糖脂代谢 

分 类 号：R587[医药卫生—内分泌] R966[医药卫生—内科学]