血清CD62p在冠心病患者中的表达及其临床意义  

Serum levels of CD62p expression and its clinical significance in patients with coronary heart disease

作　　者：仇玉民[1] 张波涛[1] 刘志军[1] 马巧红[2] 徐烨华 熊爱琴 马萍[1] 

机构地区：[1]宁夏医科大学总医院心脑血管病医院心内科,宁夏银川750002 [2]宁夏医科大学,宁夏银川750004

出　　处：《宁夏医学杂志》2015年第5期414-415,共2页Ningxia Medical Journal

基　　金：宁夏科技攻关资助项目(2010168)

摘　　要：目的观察血清CD62p在冠心病患者中的表达水平,并探讨其临床意义。方法共选择实验对象179例,其中A组稳定型心绞痛(SAP)患者32例,B组不稳定型心绞痛(UAP)患者66例,C组急性心肌梗死(AMI)患者39例,D组健康对照人群42例。各组确诊后分别抽取外周静脉血,应用酶联免疫吸附剂测定(ELISA)法测定血中CD62p的水平。结果 A、B、C组患者服药前血清中CD62p水平均高于D组(P<0.05),且对于冠心病患者,AMI组高于UAP组(P<0.05),UAP组高于SAP组(P<0.05)。结论冠心病患者血清CD62p水平高于健康人群,不同类型冠心病患者血清中的CD62p水平存在差异。Objective To observe serum levels of CD62 p expression and its clinical significance in patients with coronary heart disease（ CHD）. Methods Experimental subjects were selected 179 cases,including SAP patients with 32 cases（ group A）,UAP patients with 66 cases（ group B）,AMI patients with 39 cases（ group C） and 42 cases of healthy control subjects（ group D）,serum concentration of CD62 p was measured by Elisa. Results Concentration of CD62 p in group A,B and C were higher than that in D group（P〈0. 05）,and that in C group higher than B group（P〈0. 05）,that in B group higher than A group（P〈0. 05）. Conclusion The concentration of serum CD62 p in patients with CHD is higher than that of the healthy control group,the serum concentration of CD62 p in different types of patients with CHD was different.

关 键 词：冠心病 P选择素 

分 类 号：R541.4[医药卫生—心血管疾病]