O-磺化/O-季铵化-N,N-双烷基壳聚糖混合单分子膜及自组装囊泡性质  

Mixed monolayers and self-assembly vesicles of O-sulfonated-N,Ndilauryl chitosan/O-quaternized-N,N-dilauryl chitosan

作　　者：毛扬帆[1] 李明春[1] 辛梅华[1] 

机构地区：[1]华侨大学材料科学与工程学院环境友好功能材料教育部工程中心,福建厦门361021

出　　处：《化工进展》2015年第5期1365-1370,共6页Chemical Industry and Engineering Progress

基　　金：福建省重点科技项目(2009H0030);福建省自然科学基金(2012J01396和2011J01312);科技部科技人员服务企业项目(2009GJC40030)

摘　　要：制备了具有良好油溶性的O-磺化-N,N-双十二烷基壳聚糖（HSDLCS）和O-季铵化-N,N-双十二烷基壳聚糖（QADLCS）,研究了HSDLCS/QADLCS混合单分子膜和自组装囊泡性质的关系。结果表明,混合单分子膜的崩溃压（46.14m N/m）和最大压缩模量（Cs,max-1,98.85m N/m）较相应的单组分大;自组装形成球形囊泡的粒径在200~400nm;以维生素B12为模型药物制备HSDLCS/QADLCS复合囊泡的载药量为0.1987mg/mg,包封率为38.25%,药物平衡释放率为23.68%。静电作用使得混合单分子膜的凝聚性和抗形变能力更强,复合囊泡药物通透性降低,结构更紧密。单分子膜的Cs,max-1与其相应载药囊泡药物平衡释放率呈一定的线性关系。Oil-soluble O-sulfonated-N,N-dilauryl chitosan（HSDLCS） and O-quaternized-N,N-dilauryl chitosan（QADLCS） with similar substitution were synthesized. The properties of mixed monolayers and self-assembly vesicles of HSDLCS and QADLCS were studied. The mixed monolayers had larger collapse pressure（πc） larger maximum compression modulus（Cs,max-1） and limited molecular area（Aex） compared with HSDLCS and QADLCS monolayers. Spherical self-assembly vesicles were formed in diameter 200—400nm. Using Vitamin B12 as model drug,drug loading and encapsulation efficiency of complex vesicles were 0.1987 mg/mg and 38.25%,and equilibrium rates of Vitamin B12 release was 23.68%. Electrostatic attraction existing between the hydrophilic groups of HSDLCS and QADLCS resulted in stronger anti-deformation ability and cohesion of the mixed monolayers,decreased drug permeability of complex vesicles,and more tight structure of vesicles. Therer was a linear relationship between the Cs,max-1 of monolayers and equilibrium drug-release rate of the vesicles.

关 键 词：壳聚糖 磺化 季铵化 双烷基化 单分子膜 囊泡 

分 类 号：O636.1[理学—高分子化学]