益气活血中药血液透析液对慢性肾功能衰竭患者血小板膜糖蛋白CD62P表达的影响  

Influence of Chinese Herbs on the Expression of Platelet Membrane Glycoprotein CD62P for Blood Dialysis Patients with Chronic Renal Failure

作　　者：何学鹏[1] 杨凯[1] 陈鹏[1] 刘兵[1] 张媛[1] 王芳[1] 郭智[1] 刘晓东[1] 楼金星[1] 陈惠仁[1] 

机构地区：[1]北京军区总医院血液科,北京100700

出　　处：《血栓与止血学》2015年第2期116-118,121,共4页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的分析益气活血中药血液透析液对慢性肾功能衰竭(CRF)患者血小板膜糖蛋白CD62P表达的影响。方法选取我科2012年1月至2014年1月长期接受血液透析的CRF患者92例,随机分为实验组和对照组。对照组采用碳酸氢盐血液透析液,实验组在对照组基础上,加用益气活血中药。对比两组患者透析3个月后中医症候评分、血生化、和血清CD62P水平。结果治疗3个月后,两组患者的中医症候评分较治疗前显著降低(P<0.05);实验组治疗3个月后中医症候评分较对照组显著降低(P<0.05)。治疗3个月后,两组患者的血肌酐、尿素氮、血钾、血磷和免疫反应性甲状旁腺激素(i PTH)较治疗前显著降低,血钙较治疗前显著上升(P<0.05);治疗3个月后,实验组的血肌酐、尿素氮、血钾、血磷和i PTH较对照组显著降低,血钙较对照组显著上升(P<0.05)。治疗3个月后,实验组的红细胞、血红蛋白和尿渗透压较对照组显著升高,尿ACR较对照组显著降低,(P<0.05)。治疗3个月后,两组患者的血清CD62P水平较治疗前显著降低(P<0.05);治疗3个月后,实验组血清CD62P水平较对照组显著降低(P<0.05)。结论益气活血中药血液透析液用于CRF患者透析可降低其CD62P水平,改善肾功能,具有一定的应用价值。Objective To analyze the impact of Chinese herbs for platelet membrane glycoprotein CD62 P expression in blood dialysis patients with chronic renal failure（ CRF）. Methods 92 CRF cases with long-term hemodialysis in our department from January 2012 to January 2014 were randomly divided into experimental and control groups. The control group had bicarbonate dialysis fluid; the experimental group was based on the use of Chinese herbs added. The TCM symptom score,blood biochemistry,and serum CD62 P levels were compared in two groups of patients 3 months after dialysis. Results After 3 months of treatment,TCM symptom score in both groups was significantly lower than before treatmen（ P 〈 0. 05）. TCM symptom scores in the experimental group 3 months after treatment were significantly lower than the control group（ P 〈0. 05）. After three months of treatment,serum creatinine,blood urea nitrogen,potassium,phosphorus and immunoreactive parathyroid hormone（ i PTH） in both groups of patients were significantly lower than those before treatment,serum calcium was significantly higher（ P 〈 0. 05）. 3 months after treatment,serum creatinine,blood urea nitrogen,potassium,phosphorus and i PTH in the experimental group were significantly lower than those of the control group,serum calcium was significantly higher,P 〈 0. 05. and urine osmotic pressure in the experimental group. After three months of treatment,the serum levels of CD62 P in both groups were significantly lower than before treatment（ P 〈 0. 05）; 3 months after treatment,the serum levels of CD62 P significantly decreased in the experimental group than in the control group（ P 〈 0. 05）. Conclusion Yiqihuoxue medicine for hemodialysis patients with CRF dialysis fluid can reduce the CD62 P levels and improve kidney function with a certain value.

关 键 词：血小板膜糖蛋白CD62P 血液透析 益气活血中药 慢性肾功能衰竭 

分 类 号：R692.5[医药卫生—泌尿科学]