参松养心胶囊治疗冠心病室性早搏随机对照试验的系统评价  

Systematic Review of Shensong Yangxin Capsule for Treatment of Ventricular Premature Complexes in Coronary Artery Disease

作　　者：张萍[1] 吴立旗[1] 杨虹婕[1] 李博[1] 徐凤芹[1] 马晓昌[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《中西医结合心脑血管病杂志》2015年第4期460-463,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的评价参松养心胶囊治疗冠心病室性早搏的有效性及安全性。方法计算机检索PubMed、Cochrane图书馆临床试验注册数据库、中国生物医学文献数据库(Web版)、中文生物医学期刊数据库(Web版)CMCC、VIP中文科技期刊数据库(Web版)、CNKI中国期刊全文数据库(Web版)、万方数据库,筛选参松养心胶囊治疗冠心病室性早搏的随机对照试验(RCT)或半随机对照试验。用Jadad评分对纳入研究报告质量进行评价,RevMan5.1.4软件进行Meta分析。结果共检索到有关参松养心胶囊的文献51篇,经过初筛和严格评价,符合纳入标准的15篇,最终进入Meta分析共3篇。3项研究均比较了参松养心胶囊和心律宁片(苦参碱制剂)治疗冠心病室性早搏的疗效、心电图疗效、中医证候疗效及不良反应情况。纳入研究的Jadad评分≥3分。对3项研究的室性早搏有效率合并效应量检验,PP分析结果:RR(fixed)=1.37,95%CI(1.18,1.59),P<0.000 1;ITT分析结果:RR(fixed)=1.31,95%CI(1.15,1.54),P<0.000 1。心电图疗效评价显示:RR(fixed)=1.48,95%CI(1.15,1.90),P=0.002。中医证候疗效显示:RR(fixed)=1.34,95%CI(1.21,1.49),P<0.000 1。结论参松养心胶囊可能为一种治疗冠心病室性早搏的有效药物,但尚需要更多高质量研究以增加证据的强度。Objective To assess the effectiveness and safety of Shensong Yangxin capsule（SYC）in the treatment of ventricular premature complexes（VPC）in coronary artery disease（CAD）.Methods We searched the literature associated with randomized control ed trials（RCT）or quasi RCT of traditional Chinese medicine（TCM）in treating CAD patients with VPC from PubMed（update to Feb 2011）,Chinese Biology Medicine disc For Internet （CBM Web）（update to Feb 2011）,Chinese Medical Current Content （CM-CC）（update to Feb 2011）,VIP Chinese science and Technology Periodical Database （update to Feb 2011）,CNKI China Journal Ful text Database（update to Feb 2011）,and Wan Fang Database（update to Feb 2011）.Quality of them was evaluated by the method—Jadad score,and statistical analysis was performed using the Cochrane Col aboration’s Rev Man 5.1.4 software.Results The treated group was given SYC,while the control group was given matrine tablet in al the three trials.And they al compared the effectiveness,ECG effectiveness,syndrome of traditional Chinese Medicine and safety.Al the included were greater than or equal to score three （Jadad score）.The combined effect of inspection about VPC effectiveness showed as fol ow.Per protocol analysis showed RR（fixed）= 1.37,95%CI （1.18,1.59）,P〈0.000 1.Intention to treat analysis showed RR（fixed）= 1.31,95%CI （1.15,1.54）,P〈0.000 1. ECG effectiveness shoued that RR（fixed）= 1.48,95%CI （1.15,1.90）,P= 0.002.Syndrome of TCM：RR（fixed）= 1.34,95%CI （1.21,1.49）, P〈0.000 1.Conclusion According to the present evidence,SYC is effective in the treatment of VPC in CAD.But more wel designed randomized control ed trials are required.

关 键 词：分别作为主题词和自由词进行检索 并使 冠心病 室性早搏 参松养心胶囊 系统评价 

分 类 号：R259[医药卫生—中西医结合]