ACS患者不同Hcy、MAPK水平与病情严重程度的关系探讨  

Relationship between the Levels of Homocysteine and Mitogen-activated Protein Kinases with Severity of Disease in Acute Coronary Syndrome

作　　者：金鹏[1] 周琪[1] 张敏莉[1] 

机构地区：[1]中国石油天然气集团公司中心医院,河北廊坊065000

出　　处：《中西医结合心脑血管病杂志》2015年第4期536-538,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨急性冠脉综合征(ACS)患者不同同型半胱氨酸(Hcy)和丝裂原活化蛋白激酶(MAPK)水平与病情严重程度的关系。方法将208例ACS患者采用ELISA法分别测定其外周血Hcy和MAPK水平,根据其值分为非高同型半胱氨酸(A组,106例)及高同型半胱氨酸(B组,102例);冠状动脉病变支数根据冠状动脉造影结果评定。发病1个月后应用心脏超声测定心脏射血分数(LVEF)。结果 A组单支血管病变比例显著高于B组(P<0.01),B组双支血管病变及三支血管病变比例显著高于A组(P<0.01)。B组MAPK浓度较A组明显升高(P<0.05),LVEF较A组明显降低(P<0.01)。结论同型半胱氨酸可作为ACS患者病情严重程度的预测指标。而MAPK可作为ACS患者在应用同型半胱氨酸评价预后的补充。Objective To investigate the relationship between the levels of homocysteine（Hcy）and mitogen activated protein kinases （MAPK）and severity of disease in patients with acute coronary syndrome（ACS）.Methods Two hundreds and eight patients with ACS were measured with levels of MAPK and Hcy by ELISA.The patients were divided into two groups：Group A [non homocysteine （NHhcy）group,n= 106]and group B [homocysteine（Hhcy）group,n= 102].The coronary lesion count was assessed according to CAG.One month after the onset,cardiac ultrasound measurement applications was used to evaluate heart ejection fraction （LVEF）.Results The proportion of single vessel lesion in group A was higher than that in group B（P〈0.01）.The proportion of double and three vessel lesion in group B was higher than that in group A（P〈0.01）.The concentration of MAPK in group B was higher than that in group A（P〈0.05）.The LVEF in group B was lower than that in group A（P〈0.05）.Conclusion Hcy can be as a predictor of disease severity in patients with ACS.MAPK can be as a supplement of prognosis evaluation in ACS patients by the application of Hcy.

关 键 词：急性冠脉综合征 同型半胱氨酸 丝裂原活化蛋白激酶 

分 类 号：R541.4[医药卫生—心血管疾病] R256.2[医药卫生—内科学]