2-氯-N-[6-(3-氯-苯氧基)-吡啶-3-基甲基]-烟酰胺的合成与杀菌活性  

Synthesis and Fungicidal Activity of 2-Chloro-N-[6-(3-chlorophenoxy)-pyridin-3-ylmethyl]-nicotinamide Derivatives

作　　者：程玉龙[1] 谢勇[2] 关爱莹[2] 徐浩[1] 房晓敏[1,3] 丁涛[1,3] 

机构地区：[1]河南大学精细化学与工程研究所,河南开封475004 [2]沈阳化工研究院有限公司新农药创制国家重点实验室,沈阳110021 [3]阻燃与功能材料河南省工程实验室,河南开封475004

出　　处：《农药》2015年第5期321-323,共3页Agrochemicals

基　　金：河南省科技发展计划项目(134300510072)

摘　　要：[目的]在新农药创制研究中,寻找高活性化合物。[方法]利用"中间体衍生化"方法,经设计、合成了12个2-氯-N-[6-(3-氯-苯氧基)-吡啶-3-基甲基]-烟酰胺类化合物。以2-氯-5-氰基吡啶为起始原料经多步反应生成目标化合物,所有结构均经核磁共振氢谱验证,并对合成的化合物进行了室内杀菌活性筛选。[结果]初步生物活性测试结果表明:在普筛条件下此类化合物有良好的杀菌活性,质量浓度为400 mg/L时,化合物C4、C12表现出良好的广谱杀菌性。[Aims] The paper aims to find new compounds with highly bioactivity. [Methods] Twelve target compounds were designed and synthesized from the starting material of 2-chloro-5-cyanopyridine by using intermediate derivatization method. The structures of target compounds were confirmed by 1H NMR. All the compounds were tested of indoor fungicidal activity. [Results] The bioassay showed that most of them have favorable bactericidal activity. And the compound C4 and C12 exhibited broad-spectrum bactericidal activity at the concentration of 400 mg/L.

关 键 词：2-氯-5-氰基吡啶 中间体衍生化法 合成 生物活性 

分 类 号：TQ450.1[化学工程—农药化工]