膦甲酸钠注射液联合高能红光治疗中老年带状疱疹效果观察  

Effect of high-energy red light therapy combined with foscarnet in herpes zoster in middle-aged patients

作　　者：羊剑秋[1] 朱红柳[1] 高以红[1] 李超[1] 

机构地区：[1]江苏省江阴市中医院皮肤科,214400

出　　处：《中国医药》2015年第5期732-734,共3页China Medicine

摘　　要：目的 观察膦甲酸钠注射液联合高能红光治疗中老年带状疱疹的临床疗效.方法 选取2012年6月至2014年1月江阴市中医院皮肤科收治的85例中老年带状疱疹患者,根据随机数字表法分为观察组（45例）和对照A组（40例）,另选取李超收集并发表于《中国麻风皮肤病学》杂志的带状疱疹患者43例作为对照B组.观察组给予膦甲酸钠注射液联合高能红光治疗,对照A组给予喷昔洛韦注射液联合高能红光治疗,对照B组仅给予喷昔洛韦注射液治疗,3组疗程均为10d.比较3组患者的临床疗效及不良反应发生情况.结果 观察组的平均止痛及结痂时间与对照A组相比,差异无统计学意义（P＞0.05）,但平均止疱时间比较差异有统计学意义[（2.1±1.3）d比（3.0±1.1）d,P＜0.01].观察组和对照A组的平均止痛、止疱及结痂时间均明显短于对照B组[（3.1±1.3）、（3.2±1.6）d比（4.7±0.8）d,（2.1±1.3）、（3.0±1.1）d比（4.6±0.7）d,（5.9±1.7）、（6.1±0.5）d比（6.8±1.4）d],差异有统计学意义（P＜0.01）.观察组与对照A组有效率相比差异无统计学意义（P＞0.05）,但观察组和对照A组有效率均高于对照B组[93.3％（42/45）、92.5％ （37/40）比83.7％（36/43）],差异有统计学意义（P＜0.01）.观察组有1例发生后遗神经痛,对照A组有4例发生后遗神经痛,对照B组有5例发生后遗神经痛.3组患者不良反应比较差异无统计学意义（P＞0.05）.结论 膦甲酸钠注射液联合高能红光治疗带状疱疹可明显提高临床疗效,减少受损神经根的炎性反应,促进恢复.Objective To investigate the clinical efficacy of high-energy red light therapy combined with foscarnet in treatment of herpes zoster in the middle-aged patients.Methods Eighty five patients with herpes zoster from June 2012 to January 2014 were randomized divided into observation group （45 cases） and control group A （40 cases）,in addition,43 patients with herpes zoster in the research published in ＂ China leprosy Dermatology＂ were set as control group B.The patients received high-energy red light therapy combined with foscarnet injection in observation group,received high-energy red light therapy combined with penciclovir injection in control group A,and received penciclovir injection only in control group B.After 10 days of treatment,the efficiency and adverse reactions were observed and compared among the three groups.Results The time of pain relieving and incrustation in observation group showed no significant differences compared with control group A （P ＞ 0.05）,while the herpes stopping time in observation group was shorter than that in control group A [（2.1 ± 1.3） d vs （3.0 ± 1.1）d,P ＜0.01].The time of pain relieving,herpes stopping and incrustation in obserbvation group and control group A were significantly shorter than those in control group B [（3.1 ± 1.3）,（3.2 1.6） d vs （4.7 ± 0.8） d;（2.1±1.3）,（3.0±1.1） dvs （4.6±0.7） d;（5.9±1.7）,（6.1±0.5） dvs （6.8±1.4） d] （P ＜0.01）.Efficiency in control group A showed no significant difference compared with that in observation group,both being significantly higher than that in control group B [93.3％ （42/45）,92.5％ （37/40） vs 83.7％ （36/43）] （P ＜ 0.01）.Postherpetic neuralgia occurred in 1 case of observation group,4 cases of control group A and 5 cases of control group B.There were no significant differences of adverse reactions among the three groups.Conclusion High-energy red light therapy in treatment of herpes zoster in the middle-aged patients combined with foscarne

关 键 词：带状疱疹 膦甲酸钠 高能红光 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]