CT增强扫描中碘佛醇的不良反应及应对方法研究  

Study on Adverse Reactions of Ioversol in CT Enhanced Scan and Their Coping Methods

作　　者：李文尧[1] 杨晓萌[1] 

机构地区：[1]四川大学医院,四川成都610000

出　　处：《中国药业》2015年第9期82-83,共2页China Pharmaceuticals

摘　　要：目的观察并探讨CT增强扫描中碘佛醇的不良反应及应对方法。方法选择2012年6月至2014年5月行CT增强扫描并应用碘佛醇为对比剂的患者1 256例,统计所有CT增强扫描成功患者注射碘佛醇前及注射后48 h内血清学、肾功能、心电图以及其他不良反应情况。结果注射后48 h内有14例患者血肌酐值及尿素氮值均显著升高,与注射前血肌酐值、尿素氮值比较有显著性差异(P<0.05)。注射碘佛醇后Ⅱ导联、T波以及av F等心电图异常发生率为2.07%,一过性心率异常发生率为2.55%,一过性血压升高发生率为3.26%,一过性轻微热感发生率为3.82%,一过性面部潮红发生率为3.98%,头晕、恶心发生率为1.75%,注射部位即时肿胀发生率为2.71%,无中度、重度不良反应发生。结论 CT增强扫描中碘佛醇尽管不良反应发生率相对较低,但仍需引起重视,必须采取恰当的应对方法。Objective To observe the adverse reactions and coping methods of ioversol in CT enhanced scan. Methods 1 256 patients with enhanced CT scan and ioversol as contrast agent in our hospital from June 2012 to May 2014 were selected and the adverse re-actions situation of the serology, renal function, EKG, etc. before and within 0-48 h after injecting ioversol were performed the statis-tics. Results The serum creatinine and blood urea nitrogen values in 14 cases were significantly increased, which showed the statistical-ly significant differences compared with those before injecting ioversol （ P〈 0. 05 ） . The occurrence rate of EKG abnormality in lead II, T wave and avF after injection of ioversol was 2. 07%, the occurrence rate of transient abnormal heart rate was 2. 55%, which of blood pressure was 3. 26%, which of slight fever sensation was 3. 82% and which of transient facial flushing was 3. 98%, the occurrence rate of dizziness and nausea was 1. 75%, the occurrence rate of instant swelling at the injection site was 2. 71%;no moderate and severe adverse reactions occurred. Conclusion Although the adverse reaction of ioversol in CT enhanced scan has relatively lower occurrence rate, but which needs to pay attention to and the appropriate coping methods should be adopted.

关 键 词：CT增强扫描 碘佛醇 不良反应 应对方法 

分 类 号：R969.3[医药卫生—药理学] R981.1[医药卫生—药学]