无溶剂条件下以N-甲基-2-吡咯烷酮硫酸氢盐为离子液体催化剂高效、环境友好一锅法合成1,5-苯二氮衍生物(英文)  

Efficient, environmentally benign, one-pot procedure for the synthesis of 1,5-benzodiazepine derivatives using N-methyl-2-pyrrolidonium hydrogen sulphate as an ionic liquid catalyst under solvent-free conditions

作　　者：Hossein Naeimi Hossein Foroughi 

机构地区：[1]Department of Organic Chemistry, Faculty of Chemistry, University of Kashan

出　　处：《催化学报》2015年第5期734-741,共8页

基　　金：University of Kashan for supporting this work by Grant No: 159148/55

摘　　要：A powerful and environmentally benign method has been developed for the one-pot synthesis of 4-substituted-1,5-benzodiazepines via the three-component reaction of a series of aldehydes with dimedone and o-phenylenediamine using [H-NMP][HSO_4] as a Brnsted acidic ionic liquid catalyst under solvent-free conditions. The key benefits of this new method over existing techniques include high yields, the use of a green catalyst, short reaction times and facile catalyst separation.A powerful and environmentally benign method has been developed for the one-pot synthesis of 4-substituted-l,5-benzodiazepines via the three-component reaction of a series of aldehydes with dimedone and o-phenylenediamine using [H-NMP][HSO4] as a Br6nsted acidic ionic liquid catalyst under solvent-free conditions. The key benefits of this new method over existing techniques include high yields, the use of a green catalyst, short reaction times and facile catalyst separation.

关 键 词：离子液体催化剂 无溶剂条件 一锅合成 邻苯二胺 环境友好 二氮杂 N-甲基 硫酸氢 

分 类 号：O625.6[理学—有机化学]