肥胖、IGT、2型糖尿病患者与健康人血浆胰多肽水平的观察  

Observation on plasma pancreatic polypeptide level in patients with obesity,IGT and T2DM and healthy persons

作　　者：何雷[1] 年碧霄[1] 赵星辰[1] 周斌[1] 谭泽世[1] 尹翰鹏 欧阳奋竞[1] 叶仁青[1] 

机构地区：[1]南方医科大学珠江医院内分泌科,广州510282

出　　处：《重庆医学》2015年第13期1777-1778,1781,共3页Chongqing medicine

摘　　要：目的探讨肥胖、糖耐量异常(IGT)、2型糖尿病患者与健康人血浆胰多肽(PP)水平的变化及意义。方法肥胖、IGT、2型糖尿病患者及健康对照者共47例,测定其基础、标准蛋白餐后15、30、60、120min血浆PP及空腹血糖、胰岛素,比较并观察在肥胖、IGT、2型糖尿病患者中不同水平PP的意义。结果单纯肥胖组PP水平最低,肥胖伴糖耐量异常组及2型糖尿病组PP水平升高。结论肥胖、IGT、2型糖尿病患者中可能出现了影响PP分泌的自主神经功能改变。Objective To explore the changes and significance of plasma pancreatic polypeptide（PP） levels in the patients with obesity or impaired glucose tolerance（IGT） or type 2 diabetes mellitus（T2DM） and the healthy controls. Methods Forty-- seven persons of T2DM or IGT or obesity or normal control were determined plasma PP in the basic condition, at 15,30,60,120 min after standard protein dinner and the signiifcance of different levels of PP in the patients with obesity,IGT and T2DM was ob- served and compared. Results The plasma PP level in the obesity group was lowest and which in the IGT group and the T2DM group was increased. Conclusion The autonomic nervous function change affecting the PP secretion could be appeared in the patients with obesity,IGT and T2DM.

关 键 词：糖尿病 2型 胰多肽 胰岛素 自主神经 

分 类 号：R587.1[医药卫生—内分泌] R446[医药卫生—内科学]