三七提高高原人体作业能力的现场研究  

Field Study on Pahax notoginseng Tablets Improving Operational Capability in Human Body at High Altitude

作　　者：崔建华 高亮 张钢[2] 李年华 王琰 阳盛洪 李彬 王福领 

机构地区：[1]解放军18医院全军高山病防治研究中心,新疆叶城844900 [2]第三军医大学高原军事医学系高原医学教育部全军高原生理与高原病研究重点实验室,重庆400038

出　　处：《解放军药学学报》2014年第6期497-501,共5页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：国家科技支撑计划项目;No.2009BAI85B06;高原医学教育部重点实验室资助项目;No.2011JSGY05

摘　　要：目的探讨三七对提高移居高原人群体力作业能力的影响。方法在海拔3700、5100 m分别选择青年40人,随机分为2组,每组20人。三七组口服三七片,每次4片,对照组口服安慰剂,每次2粒,均每日2次,连续服用15 d。按军用卫生标准《士兵体能的测量和评价》GJB1337-92测定服药前、后体能指标,采集静脉血检测服药前、服药前运动后及服药后运动后血中谷丙氨酸氨基转移酶(ALT)、谷草氨酸氨基转移酶(AST)、总胆红素(TB)、直接胆红素(DB)、一氧化氮(NO)及一氧化氮合酶(NOS)、超氧化物歧化酶(SOD)、丙二醛(MDA)、血乳酸(BLA)及尿素氮(BUN)的含量。结果 (1)海拔3700 m:较服药前,PWC170、台阶指数增高,一、二级负荷心率(HR)降低(P<0.05或P<0.01);较对照组服药后,VO2max、PWC170、台阶指数增高,一、二级负荷HR降低(P<0.05或P<0.01)。与服药前比较,ALT、AST、TB、DB、BUN、BLA降低,SOD、NO、NOS增高(P<0.05或P<0.01);较对照组服药后,AST、TB、DB、BUN降低,SOD增高(P<0.05或P<0.01)。(2)海拔5100 m:较服药前,PWC170、台阶指数、Sa O2增高,一级负荷HR降低(P<0.05或P<0.01);较对照组服药后,一级负荷HR降低(P<0.05)。与服药前比较,ALT、AST、TB、DB、MDA降低,NOS增高(P<0.05或P<0.01);较对照组服药后,AST、TB、DB、MDA、BLA降低(P<0.05或P<0.01)。结论三七具有抗疲劳、抗缺氧,提高高原人体运动能力,可能与其减轻低氧环境对脏器的损害有关。Objective To explore the effect pahax notoginseng tablets on physical work capacity of the militarg at high altitude.Methods 40 young people were respectively chosen and randomly divided into 2 groups（pahax notoginseng tablet group,n = 20;and control group,n = 20） at an altitude of 3700 m and 5100 m.The two groups were given oral pahax notoginseng tablets and placebo respectively,twice a day for 15 days.The physique index of exercise of the two groups was messured according to the National Military Criteria（GJB1337-92）pre-and post-treatment while their blood samples were collected and the level of ALT,AST,TB,DB,NO,NOS,SOD,MDA,BLA and BUN was measured.Results（1） 3700 m：Compared with pre-treatment,the PWC170 and the step index were raised while the HR of the first-level and secoud-level load was reduced（P 〈 0.05 or P 〈 0.01）,compared with control group（post-treatment）,VO2 max,index of step was raised,while the HR of the first-level and secoud-level load was reduced（P 〈 0.05 or P 〈 0.01）.Compared with pre-treatment,the level of ALT,AST,TB,DB,BUN and BLA was reduced,but the level of SOD,NO and NOS was increased（P 〈 0.05 or P 〈 0.01）,compared with control group（post-treatment）,the level of AST,TB,DB and BUN was reduced while the level of SOD was increased（P 〈 0.05 or P 〈 0.01）.（2） 5100 m：Compared with pre-treatment,PWC170 and the step index and Sa O2 were increased while the HR of the first-level load was reduced（P 〈 0.05 or P 〈 0.01）.Compared with control group（post-treatment）,the HR of the first-level load was reduced（P 〈 0.05）.Compared with pretreatment,the level of ALT,AST,TB,DB and MDA was reduced while the level of NOS was increased（P 〈 0.05 or P 〈 0.01）.Compared with control group（post-treatment）,the level of AST,TB,DB,MDA and BLA was reduced（P 〈 0.05 or P 〈 0.01）.Conclusion Pahax notoginseng tablets have anti-fatigue and anti-hypoxia effect,improve exercise performance of the human body,and alleviate damage to org

关 键 词：高原 三七 作业能力 

分 类 号：R961[医药卫生—药理学]