急性冠脉综合征患者血清sol-CXCL16水平及其与hs-CRP、TIMI积分的相关性  

Serum sol-CXCL16 level and its correlation with hs-CRP and TIMI scores in patients with acute coronary syndrome

作　　者：黄桂锋 李冰 郑健义 吴泽彬[2] 

机构地区：[1]广东省汕头市潮阳区大峰医院,广东汕头515154 [2]广东省汕头大学第一附属医院,广东汕头515000

出　　处：《广东医学院学报》2014年第6期781-783,共3页Journal of Guangdong Medical College

摘　　要：目的观察急性冠脉综合征(ACS)患者血清可溶性CXC趋化因子配体16(sol-CXCL16)水平及其与高敏C-反应蛋白(hs-CRP)、TIMI危险积分的关系。方法分别测定50名ACS患者、50名稳定型心绞痛患者和30名健康者血清solCXCL16和hs-CRP水平,并计算ACS患者的TIMI危险积分。结果 ACS组sol-CXCL16和hs-CRP水平明显高于其他两组,差异有统计学意义(P<0.01)。sol-CXCL16水平和TIMI危险积分呈正相关(rs=0.282,P<0.05),但其与hs-CRP水平无明显相关(r=0.352,P>0.05)。结论血清sol-CXCL16水平可能在ACS早期诊断和危险评估上有一定临床意义。Objective To observe serum sol-CXCL16 level and its correlation with hs-CRP and risk scores of thrombolysis in myocardial infarction（TIMI） in patients with acute coronary syndrome（ACS）. Methods Serum levels of sol-CXCL16 and hs-CRP were determined in 50 patients with ACS, 50 patients with stable angina pectoris（SAP） and 30 healthy subjects. TIMI risk scores were calculated in ACS cases. Results Serum levels of sol-CXCL16 and hs-CRP were higher in ACS group than those in SAP and control groups（P〈0.01）. Serum sol-CXCL16 content was positively correlated with TIMI risk scores（rs=0.282, P〈0.05）, but not with hs-CRP（r=0.352, P〉0.05）. Conclusion Serum sol-CXCL16 level may have a clinical significance in early diagnosis and risk assessment of ACS.

关 键 词：急性冠脉综合征 sol-CXCL16 HS-CRP TIMI危险积分 

分 类 号：R541.4[医药卫生—心血管疾病]