拟缺香茶菜水提物抗肿瘤作用的研究  

Study on the Antitumor Effect of Rabdosia excisoides Water Extract

作　　者：李寅超[1] 富显祖 石金金[1] 何永侠[1] 孙曼[1] 陈慧芳[1] 李继成[1] 

机构地区：[1]郑州大学药学院,郑州450001

出　　处：《天然产物研究与开发》2014年第A02期305-308,共4页Natural Product Research and Development

摘　　要：为了研究拟缺香茶菜水提物（以下简称拟水）对动物移植性肿瘤和对机体免疫功能的影响，本实验采用动物移植性肿瘤艾氏腹水癌（EAC）、肉瘤180（S180）、肝癌（HCA）、lewis肺癌为模型，以5-氟尿嘧啶（5-Fu）为阳性对照，以生理盐水（N.S）为阴性对照，观察拟水（5g／kg）的抗肿瘤作用；并通过小鼠溶血素实验和小鼠迟发性变态反应实验，观察其对机体免疫状态的影响。与阴性对照组相比，拟水在体外对EAC肿瘤细胞有较强的杀伤力，在体内除对实体型S180（抑瘤率38．83％）、HCA（抑瘤率32．03％）、Lewis肺癌（抑瘤率30．97％）有些作用外，对其他肿瘤作用不明显，与对照组相比，对机体免疫状态无明显影响。本实验得出拟水对腹水型肿瘤作用较弱，对实体型肿瘤有一定作用，且对机体免疫状态无明显影响。To study the effects of Rabdosia exdsoides water extract on transplanted tumors and the immunological influence in mice. The antltumor effects of Rabdosla excisoides water extract in 5g/kg dosage on Ehrlich ascites carcinoma （EAC） ,Sarcoma 180（S180） ,hepatoma carcinoma （HCA） ,and Lewis lung carcinoma were investigated by using the inplanted tumor animal models. The immunological effects were observed by using hemolysin and delayed hypersensitive tests inmice. The 5-Fu was used as positive control and the normal saline as blank control. It showed that Rabdosia excisoides water extract had significant cytotoxicity against EAC cell in vitro,in addition to solid models S180 （inhibition rate of 38.83% ）, hepatoma carcihoma （ inhibition rate of 32.03 % ） and Lewis lung carcinoma （inhibition rate of 30.97% ） had some effects in vivo, but on other tumor effect is not obvious, when compared with the control group, There was no prominent influence on immunological state of the animals. The experiment can show that Rabdosia excisoides water extract has a little antitumor effect on Aseites tumor and some antitumor effect on soiid models tumors,there is no obvious influence on immunological state of the animals.

关 键 词：拟缺香茶菜水提物 艾氏腹水癌 肉瘤180 肝癌 LEWIS肺癌 

分 类 号：R284.2[医药卫生—中药学]