别旁茶提取物对实验性炎症性肠病大鼠的作用  

Protection of BPC extracts on inflammatory bowel disease induced by trinitrobenzene sulfonic acid in rats

作　　者：宋雨鸿[1] 黄洁春[2] 韩亮[3] 方建志[1] 潘锦瑶[1] 蔡敬宙[1] 徐舒[4] 

机构地区：[1]广州市第一人民医院中医科,广东广州510180 [2]广东省中医院,广东广州510120 [3]广东药学院,广东广州510006 [4]广州暨南生物医药研究开发基地有限公司/暨南大学,广东广州510632

出　　处：《广东药学院学报》2015年第2期224-227,共4页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的探讨别旁茶(BPC)提取物对三硝基苯磺酸(TNBS)诱导的大鼠炎症性肠病的保护作用。方法采用TNBS灌肠建立炎症性肠病动物模型,造模结束后处死动物检测大鼠结肠组织形态学改变,检测血清肿瘤坏死因子α(TNF-α)、白介素1β(IL-1β)、白介素6(IL-6)、白介素27(IL-27)、过氧化物酶(MPO)、超氧化物歧化酶(SOD)的水平。结果 TNBS成功诱导急性实验性肠炎大鼠,与对照组相比,别旁茶提取物可显著改善TNF-α、IL-1β、IL-6、IL-27、MPO、SOD的水平(P<0.05),别旁茶高剂量组大鼠结肠组织学损伤明显改善(P<0.05)。结论别旁茶提取物对实验性炎症性肠病大鼠具有显著的保护作用。Objective To investigate the protective effect of BPC on inflammatory bowel disease （IBD） induced by trinitrobenzene sulfonic acid （TNBS） in rats. Methods Inflammatory bowel disease was induced by TNBS in rats via drainage, and colonic tissues were measured by histopathologie score. The serum levels of TNF-α,IL-1/3,IL-6,1L-27, MPO and SOD were detected. Results IBD model was successful induced. Compared with the control group, BPC can remarkably improved the levels of TNF-α, IL-1/3, IL-6, IL-27, MPO and SOD （P〈0.05）. The high dosages of BPC extracts remarkably reduced the histopathological damage in TNBS-induced colonitis （P〈0.05）. Conclusion BPC can obviously ameliorate TNBS-induced IBD in rats.

关 键 词：别旁茶 三硝基苯磺酸 炎症性肠病 

分 类 号：R285.5[医药卫生—中药学]