元胡止痛膏的抗炎镇痛作用  

Study on the anti-inflammatory and analgesic effects of Yuanhuzhitong Gao

作　　者：刘浪琪[1] 吴庆光[2] 刘四军[2] 李耿[2] 刘建兴[2] 

机构地区：[1]广州体育学院门诊部,广东广州510500 [2]广州中医药大学中药学院,广东广州510006

出　　处：《广东药学院学报》2015年第2期231-234,共4页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省中医药局资助项目(20131281)

摘　　要：目的研究元胡止痛膏的抗炎、镇痛作用。方法采用热板法及扭体法实验考察小鼠镇痛作用,应用小鼠耳郭肿胀、棉球肉芽肿胀及足跖肿胀实验综合评价元胡止痛膏的抗炎作用。结果元胡止痛膏各剂量组在给药后30 min、60 min、120 min均能提高小鼠的痛阈值(P<0.05),并呈现剂量依赖性;除元胡止痛膏低剂量组外,其余各组均能显著延长乙酸所致扭体小鼠的潜伏期(P<0.05),显著减少扭体次数(P<0.05);对二甲苯引起的小鼠耳郭肿胀均有显著的抑制作用(P<0.05);元胡止痛膏中、高剂量组对棉球肉芽肿有显著的抑制作用(P<0.05);除元胡止痛膏低剂量组在给药后30 min与空白对照组比较差异无统计学意义外,其余各剂量组的足跖容积净增加值在给药后30 min、60 min、90 min与空白对照组比较差异有统计学意义(P<0.05)。结论元胡止痛膏具有显著的抗炎、镇痛作用。Objective To study the anti-inflammatory and analgesic effects of Yuanhuzhitong Gao （YHZTG）. Methods Acetic acid writhing method and hot plate method were used to study the analgesic effect on mice. Dimethylbenzene-induced auricular swelling, cotton-pellet-induced granuloma, and carrageen-induced pedal edema in mice were observed for evaluation of the anti-inflammatory and analgesic effects of YHZTG. Results YHZTG treatment significantly increased the pain threshold in mice after 30,60 and 120 rain （P〈0.05） in a dose-dependent manner. YHZTG markedly prolonged the incubation period writhing, except the low-dose group, and reduced the number of writhing induced by acetic acid （ P〈0. 05）. YHZTG also significantly restrained ear tumefaction （ P 〈 0.05 ） , inhibited the formation of granuloma, except the low-dose group, and reduced the net increase of paw volume in mice after 30,60 and 120 min compared with the model group （P〈0.05）. Conclusion YHZTG shows the anti-inflammatory and analgesic effects.

关 键 词：元胡止痛膏 抗炎 镇痛 药效学评价 

分 类 号：R285.5[医药卫生—中药学]