盆腔炎性疾病患者血清AMH水平规律初探  

Study on the level of anti-Mullerian hormone in patients with pelvic inflammatory disease

作　　者：杨旭辉[1] 张杰[1] 黄志承[1] 梁嘉颖[1] 杨少芬[1] 朱照平[1] 何峰[2] 刘风华[1] 

机构地区：[1]广东省妇幼保健院生殖健康与不孕症科,广东广州510008 [2]中山大学药学院,广东广州510008

出　　处：《广东药学院学报》2015年第2期263-268,共6页Academic Journal of Guangdong College of Pharmacy

基　　金：国家自然科学基金(30900729)

摘　　要：目的调查不同程度盆腔炎性疾病（pelvic inflammatory disease,PID）患者血清抗苗勒管激素（antiMullerian hormone,AMH）水平并与正常生育期女性血清AMH水平比较,以探讨PID患者AMH的表达规律及临床意义。方法选择健康女性67例为对照组,轻中度PID患者121例、重度PID患者34例为观察组,各组再按年龄分为5组：〈25岁A组、26~30岁B组,31~35岁C组、36~40岁D组、〉40岁E组。ELISA法检测血清AMH水平并分析各组不同年龄段的分布规律及表达差异。结果轻中度PID患者血清AMH平均（4.48±0.36）ng/m L,与年龄呈负相关（r=-0.432,P〈0.01）,即AMH随年龄的增长不断下降;A组、B组均值与C组、D组、E组比较差异均有统计学意义（P〈0.01）,E组与A、B、C组比较差异也有统计学意义（P〈0.01）。重度PID患者血清AMH平均（2.12±0.26）ng/m L,与年龄呈负相关（r=-0.428,P〈0.05）,AMH随着年龄的增长下降幅度不大,但40岁后女性AMH骤降;E组与其余各组比较,差异均有统计学意义（P〈0.01）。对照组血清AMH平均（3.91±0.51）ng/m L,与年龄呈负相关（r=-0.742,P〈0.01）,即AMH随年龄的增长不断下降;E组与其余各组两两比较,差异均有统计学意义（P〈0.01）,A、B组与C、D、E组两两比较差异也有统计学意义（P〈0.05）。不同年龄组重度PID患者与轻中度PID患者、对照组血清AMH均值比较差异有统计学意义（P〈0.05）。结论年龄是影响PID患者和正常生育期女性血清AMH水平的重要因素,重度PID患者与轻中度PID患者、正常女性血清AMH水平在不同年龄段均有差异;轻中度PID患者血清AMH水平可参照正常生育期女性的水平。Objective To investigate the level of serum anti-Mullerian hormone （AMH） in patients with pelvic inflammatory disease （PID） and normal population, and explore the expression pattern and clinical significance of AMH in PID patients. Methods A total of 155 PID patients and 67 healthy women participated in this study. All the subjects were divided into five groups according to age, such as group A including less than 25 years old, group B including 25 to 30 years old, group C including 31 to 35 years old, group D including 36 to 40 years old, and group E including more than 40 years old. Serum AMH level was measured by ELISA and analyzed by SPSS 16.0. Results The average AMH level was （4.48±0.36） ng/mL in patients with mild and moderate PID. and was negatively correlated with age （r =-0. 432, P〈0.01）.There was a statistical difference between groups A, B and groups C, D and E （P〈O.05）, and between group E and groups A,B and C （P〈0.01）. The average AMH level was （2.12±0.26） ng/mL in patients with severe PID, and was negatively correlated with age （r= 0. 428, P〈0.05 ）. The level of serum AMH markedly dropped in more than 40 years old women. There was a statistical difference between group E and other groups （P〈0.01）. The average AM H level was （3.91 ±0.51） ng/mL in normal women, and the level of serum AMI-I was negatively correlated with age （r=-0.742,P〈0.01 ）. There was a statistical difference between group E and other groups （P〈0.01）. There was a statistical difference of the average AMH level between serious PID patients and moderate PID patients as well as normal women based on the same age （P〈0.05）. Conclusion Age is an important factor affecting the level of AMH in normal women and PID patients. There is a significant difference of the serum AMH levels between PID patients and normal women based on the same age.

关 键 词：抗苗勒管激素 盆腔炎性疾病 年龄 卵巢储备 

分 类 号：R711.33[医药卫生—妇产科学]