“毒损肾络”与糖尿病肾病炎症机制的相关性  

Correlation of Du Impaired Shen Channles and Diabetic Nephropathy Inflammatory Mechanism

作　　者：麻丽娜[1] 孙新宇[1] 

机构地区：[1]河南中医学院第二附属医院,河南郑州450002

出　　处：《中医学报》2015年第4期487-489,共3页Acta Chinese Medicine

基　　金：河南省教育厅自然科学研究计划项目(009A360014);河南省教育厅科技攻关项目(2011A360016)

摘　　要：糖尿病肾病(Diabetic nephropathy,DN)由于消渴病日久,耗气伤阴,病情迁延,阴损及阳,渐致痰、郁、湿、热等病理产物瘀阻血脉,津血交换受阻,废物积聚日久成毒,毒(糖毒、脂毒)随邪生入络,伏藏不去。病变涉及全身脏腑和经络,故毒邪贯穿糖尿病肾病的始终,尤以"毒损肾络"为病机核心。现代医学认为,DN发病的过程中损伤肾小管上皮细胞产生炎症因子,继而加重肾脏病变导致肾小球硬化、肾小管间质纤维化,也出现临床水肿、蛋白尿、血栓等表现。这与中医消渴病的"毒损肾络"病理变化相似。瘀阻血脉实质上就是肾脏血流动力学改变的基本表现,也就是血栓和动脉粥样硬化形成的病理基础。The patients of diabetic nephropathy（DN） for a long time had been poisoned, it＇s called Du, caused by impail^aent Yin due to consume Qi, deficiency of Yin affecting Yang, so phlegm, dampness, stagnancy, heat blocked the blood vessel, the exchange of Jin and blood had been suffocated. Du with the evil enter into the channels ,then the lesion involving the zang-fu organs and meridians. So Du run though the process of DN. The pathogenesis is Du impaired Shen channels. The inflammation factors have been generated patho- genesis of DN damage in the process of renal tubular epithelial cells, which in turn worsen kidney change lead to glomerular sclerosis, renal tubular interstitial fibrosis, also appear clinical edema,proteinuria, blood clots, etc. It＇s similar with Du impaired Shen channels. Stagnation block blood vessel is the expression of renal hemodynamic changes.

关 键 词：“毒损肾络” 糖尿病肾病 炎症机制 

分 类 号：R259.872[医药卫生—中西医结合]